Laboratory of Pathophysiological and Nutritional Biochemistry, Faculty of Medicine, Université Libre de Bruxelles, 808 Route de Lennik, Blg G/E CP 611, B-1070, Brussels, Belgium.
Department of Process Engineering and Technology of Polymer and Carbon Materials, Faculty of Chemistry, Wroclaw University of Science and Technology, Norwida 4/6, 50-373, Wroclaw, Poland.
J Biomed Sci. 2022 Jun 6;29(1):35. doi: 10.1186/s12929-022-00819-w.
Salivary gland (SG) dysfunction impairs the life quality of many patients, such as patients with radiation therapy for head and neck cancer and patients with Sjögren's syndrome. Multiple SG engineering strategies have been considered for SG regeneration, repair, or whole organ replacement. An in-depth understanding of the development and differentiation of epithelial stem and progenitor cells niche during SG branching morphogenesis and signaling pathways involved in cell-cell communication constitute a prerequisite to the development of suitable bioengineering solutions. This review summarizes the essential bioengineering features to be considered to fabricate an engineered functional SG model using various cell types, biomaterials, active agents, and matrix fabrication methods. Furthermore, recent innovative and promising approaches to engineering SG models are described. Finally, this review discusses the different challenges and future perspectives in SG bioengineering.
唾液腺（SG）功能障碍会损害许多患者的生活质量，例如头颈部癌症放疗患者和干燥综合征患者。已经考虑了多种 SG 工程策略来实现 SG 的再生、修复或整个器官替代。深入了解 SG 分支形态发生过程中上皮干细胞和祖细胞巢的发育和分化，以及参与细胞间通讯的信号通路，是开发合适的生物工程解决方案的前提。本综述总结了使用各种细胞类型、生物材料、活性剂和基质制造方法制造工程化功能性 SG 模型时需要考虑的基本生物工程特征。此外，还描述了工程化 SG 模型的最新创新和有前途的方法。最后，本文讨论了 SG 生物工程中的不同挑战和未来展望。
