滤泡辅助 T 细胞在免疫应答中的发育和功能。
The development and function of follicular helper T cells in immune responses.
机构信息
Organ Transplant Center, 1st Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
出版信息
Cell Mol Immunol. 2012 Sep;9(5):375-9. doi: 10.1038/cmi.2012.18. Epub 2012 Jun 4.
Abstract
Follicular helper T cells (Tfh) have been referred as a lineage that provides a help for B cells to proliferate and undergo antibody affinity maturation in the germinal center. Evidence has supported that Tfh subset development, like other lineages, is dependent on microenvironment where a particular transcriptional program is initiated. It has been shown that Bcl-6 and IL-21 act as master regulators for the development and function of Tfh cells. Tfh dysregulation is involved in the development of autoimmune pathologies, such as systemic lupus erythematosus, rheumatoid arthritis and other autoimmune diseases. The present review highlights the recent advances in the field of Tfh cells and focus on their development and function.
摘要
滤泡辅助 T 细胞（Tfh）被认为是为 B 细胞提供帮助，使其在生发中心增殖并进行抗体亲和力成熟的谱系。有证据表明，与其他谱系一样，Tfh 亚群的发育依赖于启动特定转录程序的微环境。已经表明，Bcl-6 和 IL-21 作为 Tfh 细胞发育和功能的主调节因子发挥作用。Tfh 失调与自身免疫性疾病的发展有关，如系统性红斑狼疮、类风湿关节炎和其他自身免疫性疾病。本综述强调了 Tfh 细胞领域的最新进展，并重点介绍了它们的发育和功能。
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本文引用的文献
1
Regulation of the germinal center reaction by Foxp3+ follicular regulatory T cells.Foxp3+ 滤泡调节性 T 细胞对生发中心反应的调节。
J Immunol. 2011 Nov 1;187(9):4553-60. doi: 10.4049/jimmunol.1101328. Epub 2011 Oct 7.
2
Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactions.表达 Foxp3 和 Bcl-6 的滤泡调节性 T 细胞抑制生发中心反应。
Nat Med. 2011 Jul 24;17(8):983-8. doi: 10.1038/nm.2426.
3
ICOS receptor instructs T follicular helper cell versus effector cell differentiation via induction of the transcriptional repressor Bcl6.ICOS 受体通过诱导转录抑制因子 Bcl6 来指示 T 滤泡辅助细胞向效应细胞分化。
Immunity. 2011 Jun 24;34(6):932-46. doi: 10.1016/j.immuni.2011.03.023.
4
Germinal center B cell and T follicular helper cell development initiates in the interfollicular zone.生发中心 B 细胞和 T 滤泡辅助细胞发育起始于滤泡间区。
Immunity. 2011 Jun 24;34(6):947-60. doi: 10.1016/j.immuni.2011.03.024.
5
A subset of interleukin-21+ chemokine receptor CCR9+ T helper cells target accessory organs of the digestive system in autoimmunity.白细胞介素 21+趋化因子受体 CCR9+辅助性 T 细胞亚群在自身免疫中靶向消化系统的辅助器官。
Immunity. 2011 Apr 22;34(4):602-15. doi: 10.1016/j.immuni.2011.01.021.
6
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J Immunol. 2011 May 15;186(10):5648-55. doi: 10.4049/jimmunol.1003161. Epub 2011 Apr 13.
7
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Annu Rev Immunol. 2011;29:621-63. doi: 10.1146/annurev-immunol-031210-101400.
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Proc Natl Acad Sci U S A. 2011 Feb 1;108(5):2010-5. doi: 10.1073/pnas.1018974108. Epub 2011 Jan 13.
9
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Annu Rev Immunol. 2011;29:665-705. doi: 10.1146/annurev-immunol-030409-101302.
10
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Immunity. 2011 Jan 28;34(1):108-21. doi: 10.1016/j.immuni.2010.12.012. Epub 2011 Jan 6.
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