MD-PhD Program, School of Medicine, Wayne State University, Detroit, MI 48201, USA; Department of Psychiatry and Behavioral Neurosciences, School of Medicine, Wayne State University, Detroit, MI 48201, USA.
Department of Pediatrics, Wayne State University, Detroit Medical Center, Detroit, MI 48201, USA; Department of Neurology, Wayne State University, Detroit Medical Center, Detroit, MI 48201, USA.
Clin Neurophysiol. 2014 Jul;125(7):1312-23. doi: 10.1016/j.clinph.2013.11.026. Epub 2013 Dec 1.
Our recent electrocorticography (ECoG) study suggested reverse speech, a widely used control task, to be a poor control for non-language-related auditory activity. We hypothesized that this may be due to retained perception as a human voice. We report a follow-up ECoG study in which we contrast forward and reverse speech with a signal-correlated noise (SCN) control task that cannot be perceived as a human voice.
Ten patients were presented 90 audible stimuli, including 30 each of corresponding forward speech, reverse speech, and SCN trials, during ECoG recording with evaluation of gamma activity between 50 and 150 Hz.
Sites of the lateral temporal gyri activated throughout speech stimuli were generally less activated by SCN, while some temporal sites seemed to process both human and non-human sounds. Reverse speech trials were associated with activities across the temporal lobe similar to those associated with forward speech.
Findings herein externally validate functional neuroimaging studies utilizing SCN as a control for non-language-specific auditory function. Our findings are consistent with the notion that stimuli perceived as originating from a human voice are poor controls for non-language auditory function.
Our findings have implications in functional neuroimaging research as well as improved clinical mapping of auditory functions.
我们最近的脑电描记术（ECoG）研究表明，反向语音作为一种广泛使用的控制任务，对于非语言相关的听觉活动来说是一种较差的控制方法。我们假设这可能是由于其被感知为人声。我们报告了一项后续的 ECoG 研究，其中我们使用无法被感知为人声的信号相关噪声（SCN）控制任务来对比正向语音和反向语音。
在 ECoG 记录期间，向 10 名患者呈现了 90 个可听刺激，包括相应的正向语音、反向语音和 SCN 试验各 30 个，评估了 50 到 150Hz 之间的伽马活动。
在语音刺激过程中，外侧颞叶的激活部位通常较少被 SCN 激活，而一些颞叶部位似乎可以处理人类和非人类声音。反向语音试验与正向语音试验相关的活动相似，涉及整个颞叶。
本研究的结果从外部验证了利用 SCN 作为非语言特定听觉功能的对照的功能神经影像学研究。我们的发现与这样的观点一致，即被感知为人声的刺激是语言听觉功能较差的控制方法。
我们的发现对功能神经影像学研究以及听觉功能的临床映射具有重要意义。
