Brown Erik C, Stedelin Brittany, Koike Seiji, Raslan Ahmed M, Selden Nathan R
Department of Neurological Surgery, Oregon Health & Science University, Portland, OR 97239, USA.
Department of Neurological Surgery, Oregon Health & Science University, Portland, OR 97239, USA.
Neuroimage. 2022 Mar;248:118840. doi: 10.1016/j.neuroimage.2021.118840. Epub 2021 Dec 24.
Processing auditory human speech requires both detection (early and transient) and analysis (sustained). We analyzed high gamma (70-110 Hz) activity of intracranial electroencephalography waveforms acquired during an auditory task that paired forward speech, reverse speech, and signal correlated noise. We identified widespread superior temporal sites with sustained activity responding only to forward and reverse speech regardless of paired order. More localized superior temporal auditory onset sites responded to all stimulus types when presented first in a pair and responded in recurrent fashion to the second paired stimulus in select conditions even in the absence of interstimulus silence; a novel finding. Auditory onset activity to a second paired sound recurred according to relative salience, with evidence of partial suppression during linguistic processing. We propose that temporal lobe auditory onset sites facilitate a salience detector function with hysteresis of 200 ms and are influenced by cortico-cortical feedback loops involving linguistic processing and articulation.
处理人类听觉语音需要检测（早期和瞬态）和分析（持续）。我们分析了在一项听觉任务中获取的颅内脑电图波形的高伽马（70 - 110赫兹）活动，该任务将正向语音、反向语音和信号相关噪声进行配对。我们确定了广泛的颞上叶部位，这些部位具有持续活动，仅对正向和反向语音做出反应，而与配对顺序无关。更局限的颞上叶听觉起始部位在一对刺激中首次呈现时对所有刺激类型都有反应，并且在某些条件下，即使在没有刺激间隔沉默的情况下，对第二个配对刺激也会以反复的方式做出反应；这是一个新发现。对第二个配对声音的听觉起始活动根据相对显著性反复出现，在语言处理过程中有部分抑制的证据。我们提出颞叶听觉起始部位促进了具有200毫秒滞后的显著性检测功能，并受到涉及语言处理和发音的皮质 - 皮质反馈回路的影响。
