信号通路揭秘：自噬与过氧化氢酶促进程序性细胞死亡。
Signaling unmasked: Autophagy and catalase promote programmed cell death.
作者信息
Petersen Morten, Hofius Daniel, Andersen Stig Uggerhøj
机构信息
Department of Biology; University of Copenhagen; Copenhagen, Denmark.
Department of Plant Biology and Forest Genetics; Swedish University of Agricultural Sciences (SLU) and Linnean Center for Plant Biology; Uppsala BioCenter; Uppsala, Sweden.
出版信息
Autophagy. 2014 Mar;10(3):520-1. doi: 10.4161/auto.27564. Epub 2014 Jan 7.
Abstract
Autophagy contributes to the removal of harmful cellular refuse, whereas catalase plays an important protective role by detoxifying reactive oxygen species. We recently found that autophagy and catalase are also required for promoting programmed cell death induced during plant immune responses. Here we discuss the difficulties in identifying cell death effectors, which are also required to maintain cellular homeostasis, and how their prodeath roles were unmasked using an unbiased forward genetics approach.
摘要
自噬有助于清除有害的细胞垃圾，而过氧化氢酶通过清除活性氧发挥重要的保护作用。我们最近发现，自噬和过氧化氢酶在促进植物免疫反应期间诱导的程序性细胞死亡中也是必需 的。在这里，我们讨论了鉴定细胞死亡效应因子（维持细胞内稳态也需要这些因子）的困难，以及如何使用无偏向性正向遗传学方法揭示它们的促死亡作用。
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