Welter H F, Siebeck M, Thetter O, Jochum M
Prog Clin Biol Res. 1987;236A:121-5.
Infusion of 3 X 10(10) live E. coli cells into anesthetized piglets induced severe septicemia with characteristic alterations in systemic and pulmonary circulation, lung function and morphology, blood cell counts and plasma protein composition. The simultaneous infusion of the elastase-cathepsin G inhibitor, r-eglin c, in a doses of 3.85 mg/kg X h for 4 hrs, reduced mortality, plasma protein consumption, and accumulation of interstitial fluid in the lungs. These findings are in favour of the concept that during septicemia the balance between liberated lysosomal proteinases and their extracellular inhibitors is severely disturbed. It can be at least partially restored by administration of an exogenous elastase inhibitor.
给麻醉的仔猪输注3×10¹⁰个活大肠杆菌可诱发严重败血症，伴有全身和肺循环、肺功能和形态、血细胞计数及血浆蛋白组成的特征性改变。同时以3.85毫克/千克·小时的剂量输注弹性蛋白酶-组织蛋白酶G抑制剂r-eglin c，持续4小时，可降低死亡率、血浆蛋白消耗及肺间质液蓄积。这些发现支持这样的观点，即在败血症期间，释放的溶酶体蛋白酶与其细胞外抑制剂之间的平衡受到严重干扰。通过给予外源性弹性蛋白酶抑制剂可至少部分恢复这种平衡。
