Siebeck M, Philapitsch A, Wiesinger H, Welter H F
Prog Clin Biol Res. 1987;236A:141-7.
In bacteremic pigs, both administered human C1INH and endogenous C1INH lost inhibitory activity. In septic pigs which received human C1INH a difference between immunologically determined concentration and inhibitory activity of C1INH became apparent. In animals which survived at least 24 hrs the C1INH activity showed an acute phase response. In a model of E. coli bacteremia in weaned pigs administration of human C1INH showed protective effects on lung capillary permeability as well as less leucocytosis.
在发生菌血症的猪中，给予的人C1INH和内源性C1INH均失去抑制活性。在接受人C1INH的败血症猪中，免疫测定的C1INH浓度与抑制活性之间的差异变得明显。在存活至少24小时的动物中，C1INH活性表现出急性期反应。在断奶仔猪的大肠杆菌菌血症模型中，给予人C1INH对肺毛细血管通透性有保护作用，白细胞增多也较少。
