挪威和意大利的阳光照射与多发性硬化症风险：EnvIMS研究。
Sun exposure and multiple sclerosis risk in Norway and Italy: The EnvIMS study.
作者信息
Bjørnevik Kjetil, Riise Trond, Casetta Ilaria, Drulovic Jelena, Granieri Enrico, Holmøy Trygve, Kampman Margitta T, Landtblom Anne-Marie, Lauer Klaus, Lossius Andreas, Magalhaes Sandra, Myhr Kjell-Morten, Pekmezovic Tatjana, Wesnes Kristin, Wolfson Christina, Pugliatti Maura
机构信息
Department of Global Public Health and Primary Care, University of Bergen, Norway Department of Neurology, The Norwegian Multiple Sclerosis Competence Centre, Haukeland University Hospital, Norway
Department of Global Public Health and Primary Care, University of Bergen, Norway Department of Neurology, The Norwegian Multiple Sclerosis Competence Centre, Haukeland University Hospital, Norway.
出版信息
Mult Scler. 2014 Jul;20(8):1042-9. doi: 10.1177/1352458513513968. Epub 2014 Jan 10.
OBJECTIVES
The objective of this paper is to estimate the association between multiple sclerosis (MS) and measures of sun exposure in specific age periods in Norway and Italy.
METHODS
A total of 1660 MS patients and 3050 controls from Italy and Norway who participated in a multinational case-control study (EnvIMS) reported sun habits during childhood and adolescence.
RESULTS
A significant association between infrequent summer outdoor activity and increased MS risk was found in Norway and in Italy. The association was strongest between the ages of 16 and 18 years in Norway (odds ratio (OR) 1.83, 95% confidence interval (CI) 1.30-2.59), and between birth and age 5 years in Italy (OR 1.56, 95% CI 1.16-2.10). In Italy a significant association was also found during winter (OR 1.42, 95% CI 1.03-1.97). Frequent sunscreen use between birth and the age of 6 years was associated with MS in Norway (OR 1.44, 95% CI 1.08-1.93) after adjusting for outdoor activity during the same period. Red hair (OR 1.67, 95% CI 1.06-2.63) and blonde hair (OR 1.36, 95% CI 1.09-1.70) were associated with MS after adjusting for outdoor activity and sunscreen use.
CONCLUSION
Converging evidence from different measures underlines the beneficial effect of sun exposure on MS risk.
目的
本文旨在评估挪威和意大利特定年龄段人群中，多发性硬化症（MS）与日照量指标之间的关联。
方法
来自意大利和挪威的1660例MS患者及3050名对照参与了一项跨国病例对照研究（EnvIMS），他们报告了童年及青少年时期的日照习惯。
结果
在挪威和意大利，均发现夏季户外不常活动与MS风险增加之间存在显著关联。在挪威，这种关联在16至18岁时最为强烈（优势比（OR）1.83，95%置信区间（CI）1.30 - 2.59）；在意大利，则是出生至5岁期间最为强烈（OR 1.56，95% CI 1.16 - 2.10）。在意大利，冬季也发现了显著关联（OR 1.42，95% CI 1.03 - 1.97）。在挪威，对同期户外活动进行校正后，出生至6岁期间频繁使用防晒霜与MS相关（OR 1.44，95% CI 1.08 - 1.93）。校正户外活动和防晒霜使用情况后，红发（OR 1.67，95% CI 1.06 - 2.63）和金发（OR 1.36，95% CI 1.09 - 1.70）与MS相关。
结论
来自不同指标的证据均表明日照对MS风险具有有益影响。
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