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99mTc-EDDA/HYNIC-奥曲肽单光子发射计算机断层显像-计算机断层扫描（SPECT-CT）与111In-喷曲肽相比在神经内分泌肿瘤检测中的诊断效能

The Diagnostic Efficiency of 99mTc-EDDA/HYNIC-Octreotate SPECT-CT in Comparison with 111In-Pentetrotide in the Detection of Neuroendocrine Tumours.

作者信息

Koçyiğit Deveci Emel, Ocak Meltem, Bozkurt Murat Fani, Türker Selcan, Kabasakal Levent, Uğur Omer

机构信息

Department of Nuclear Medicine, Hacettepe University, Ankara, Turkey.

Department of Pharmaceutical Technology, Faculty of Pharmacy, Istanbul University, Istanbul, Turkey.

出版信息

Mol Imaging Radionucl Ther. 2013 Dec;22(3):76-84. doi: 10.4274/Mirt.68552. Epub 2013 Dec 10.

DOI:10.4274/Mirt.68552
PMID:24416622
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3888016/
Abstract

OBJECTIVE

The aim of this study was to assess the diagnostic efficiency of (99m)Tc-EDDA/HYNIC-Octreotate in comparison with (111)Inpentetrotide scintigraphy in the detection of neuroendocrine tumors. This study also evaluates the impact of SPECT-CT hybrid imaging on somatostatin receptor scintigraphy (SRS) interpretation and clinical management of these tumors.

METHODS

Fourteen patients were included in the study. All patients underwent a whole body and SPECT-CT imaging with both (99m)Tc- EDDA/HYNIC-octreotate and (111)In-pentetrotide. Images were evaluated both visually and semiquantitatively.

RESULTS

On patient basis, the diagnostic results of both studies were similar. The number of lesions detected by (99m)Tc- EDDA/HYNICOctreotate were higher than the number of lesions detected by (111)In-pentetrotide however the difference was not significant (40/43( 93%), 36/43 (83%) p=0.109). Semiquantitative analysis showed higher tumor/organ count ratios for both whole-body and SPECT (99m)Tc- EDDA/HYNIC-Octreotate scans.

CONCLUSION

The results of this study suggested that, (99m)Tc- EDDA/HYNIC-Octreotate may be a better alternative to (111)In- pentetrotide due to high image quality and lower radiation dose. SPECT/CT is a valuable tool for the assessment of neuroendocrine tumors by providing the precise anatomic localization of scintigraphic findings thus improving lesion detectability and characterization.

CONFLICT OF INTEREST

None declared.

摘要

目的

本研究旨在评估（99m）Tc-EDDA/HYNIC-奥曲肽与（111）In-喷曲肽闪烁扫描法在检测神经内分泌肿瘤方面的诊断效率。本研究还评估了SPECT-CT融合成像对生长抑素受体闪烁扫描（SRS）解读及这些肿瘤临床管理的影响。

方法

14例患者纳入本研究。所有患者均接受了（99m）Tc-EDDA/HYNIC-奥曲肽和（111）In-喷曲肽的全身及SPECT-CT成像。对图像进行了视觉和半定量评估。

结果

基于患者个体，两项研究的诊断结果相似。（99m）Tc-EDDA/HYNIC-奥曲肽检测到的病灶数量高于（111）In-喷曲肽，但差异不显著（40/43（93%），36/43（83%），p = 0.109）。半定量分析显示，全身及SPECT的（99m）Tc-EDDA/HYNIC-奥曲肽扫描的肿瘤/器官计数比值更高。

结论

本研究结果表明，由于图像质量高且辐射剂量低，（99m）Tc-EDDA/HYNIC-奥曲肽可能是（111）In-喷曲肽的更好替代方案。SPECT/CT通过提供闪烁扫描结果的精确解剖定位，是评估神经内分泌肿瘤的有价值工具，从而提高了病灶的可检测性和特征描述。

利益冲突

未声明。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddd1/3888016/291ea915a47e/MIRT-22-76-g8.jpg
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