Carne R J, Drew J H
Aust N Z J Obstet Gynaecol. 1987 Feb;27(1):30-6. doi: 10.1111/j.1479-828x.1987.tb00928.x.
During the 6-year period 1971 to 1976, 10,545 patients had urinary oestriol determinations during pregnancy and 333 (3.2%) had persistently low values. Of the 335 resultant infants 206 were from patients treated with intravenous dextrose and/or amino-acids (treated group) and 129 from nontreated patients (nontreated group). The stillbirth rate was 2.4% in the treated group and 11.6% in the untreated group (p greater than 0.001), and the neonatal death rates were 2.9% and 4.7% respectively (p = NS). Assessment of the surviving infants to 7 years of age revealed no significant differences in growth between treated and nontreated groups. There was no increase in the incidence of major neurological abnormalities in the treated infants (2.9%) when compared to those from nontreated pregnancies (1.3%) (p = NS), nor was there a significant difference in the incidence of minor neurological abnormality or findings on psychological assessments. We conclude that dextrose and/or amino-acid infusions given to pregnant women with low oestriol excretion reduced the perinatal mortality rate without significant compromise to subsequent development of surviving infants.
在1971年至1976年的6年期间，10545名孕妇进行了尿雌三醇测定，其中333名（3.2%）的尿雌三醇值持续偏低。在由此产生的335名婴儿中，206名来自接受静脉输注葡萄糖和/或氨基酸治疗的患者（治疗组），129名来自未治疗的患者（未治疗组）。治疗组的死产率为2.4%，未治疗组为11.6%（p>0.001），新生儿死亡率分别为2.9%和4.7%（p=无显著性差异）。对存活至7岁的婴儿进行评估发现，治疗组和未治疗组在生长方面无显著差异。与未治疗妊娠的婴儿相比，治疗组婴儿的主要神经异常发生率（2.9%）没有增加（1.3%）（p=无显著性差异），轻微神经异常发生率或心理评估结果也没有显著差异。我们得出结论，对尿雌三醇排泄量低的孕妇输注葡萄糖和/或氨基酸可降低围产期死亡率，且不会对存活婴儿的后续发育造成显著影响。
