Drew J H, Bayly J, Beischer N A
Aust N Z J Obstet Gynaecol. 1983 Aug;23(3):150-4. doi: 10.1111/j.1479-828x.1983.tb00565.x.
Growth and neurological outcome to 7 years of age were determined in 273 growth retarded infants, 341 infants from pregnancies complicated by subnormal urinary oestriol excretion and 72 control infants. By 1 year of age 80.6% of growth retarded infants were above the 10th percentile for weight. Growth continued so that after 2 years of age only 10.6% were beneath the 10th percentile. A neurological abnormality was detected in 9.5% of growth retarded infants and 8.3% of control infants (P = NS). Only 6 (2.2%) of the growth retarded infants were severely handicapped. A neurological abnormality was detected in 16.4% of infants from pregnancies with low oestriol excretion and although this incidence was higher than that of the control infants (8.3%), the difference failed to achieve statistical significance. The neurological abnormality was severe in only 7 infants (2.1%). The intelligence quotient (IQ) was the same in infants from pregnancies complicated by chronically low oestriol excretion whether hypertonic dextrose (mean IQ 103) had been administered to the mother or not (mean IQ 105). It is concluded that the pregnancy complicated by low oestriol excretion and/or fetal growth retardation should be treated with optimism.
对273名生长发育迟缓的婴儿、341名母亲孕期尿雌三醇排泄量低于正常水平的婴儿以及72名对照婴儿进行了跟踪，直至他们7岁，以确定其生长发育情况和神经学转归。到1岁时，80.6%的生长发育迟缓婴儿体重超过第10百分位。生长发育持续进行，因此到2岁以后，只有10.6%的婴儿体重低于第10百分位。在生长发育迟缓的婴儿中，9.5%被检测出有神经学异常，对照婴儿中这一比例为8.3%（P=无显著性差异）。生长发育迟缓的婴儿中只有6名（2.2%）有严重残疾。在母亲孕期尿雌三醇排泄量低的婴儿中，16.4%被检测出有神经学异常，尽管这一发生率高于对照婴儿（8.3%），但差异无统计学意义。只有7名婴儿（2.1%）有严重的神经学异常。母亲孕期尿雌三醇排泄量长期处于低水平的婴儿，无论母亲是否接受过高渗葡萄糖治疗（平均智商103），其智商（平均智商105）并无差异。研究得出结论，对于母亲孕期尿雌三醇排泄量低和/或胎儿生长发育迟缓的情况，应持乐观态度并积极治疗。
