Wade R W, Pepperell R J, Kitchen W H, Whiteside U, Cameron S E, Townsend L
Med J Aust. 1978 May 20;1(10):525-30. doi: 10.5694/j.1326-5377.1978.tb141944.x.
In 92 pregnant women with low urinary oestriol excretion after 30 weeks' gestation, there was a higher incidence of fetal distress, premature delivery and induced labour, while resuscitation of the infant at birth was required more often than in controls. The birth weights, head circumference, and body lengths of the infants were significantly lower than those of the controls. In the 26 cases where maternal oestriol levels were persistently low, three were associated with placental sulphatase deficiency, and three infants died postnatally. Four infants had evidence of neurological defects on follow up, as did four infants in the control group. The low head circumferences, weight, and length were still present at two years of age. It is concluded that, although low oestriol excretion during pregnancy is associated with increased risk to the fetus, it is not associated per se with permanent neurological damage, provided the infant is born alive, and is congenitally normal. However, many infants remain smaller than average, at least for the first years of life.
在92例妊娠30周后尿雌三醇排泄量低的孕妇中，胎儿窘迫、早产和引产的发生率较高，而且与对照组相比，出生时需要对婴儿进行复苏的情况更常见。这些婴儿的出生体重、头围和身长明显低于对照组。在26例母亲雌三醇水平持续偏低的病例中，3例与胎盘硫酸酯酶缺乏有关，3例婴儿出生后死亡。随访时4例婴儿有神经缺陷的证据，对照组也有4例婴儿如此。这些婴儿在两岁时头围、体重和身长仍偏低。得出的结论是，虽然孕期雌三醇排泄量低与胎儿风险增加有关，但只要婴儿存活且先天性正常，其本身与永久性神经损伤并无关联。然而，许多婴儿至少在生命的最初几年仍比平均水平小。
