Nyírő Gyula Hospital, II Psychiatric Department, Lehel út 59, 1135 Budapest, Hungary.
Nyírő Gyula Hospital, II Psychiatric Department, Lehel út 59, 1135 Budapest, Hungary.
Psychiatry Res. 2014 Mar 30;215(3):651-8. doi: 10.1016/j.psychres.2013.11.014. Epub 2013 Nov 20.
Impairments in executive functioning have been identified as an underlying cause of Obsessive-Compulsive Disorder (OCD). Obsessive patients attempt to suppress certain unwanted thoughts through a mechanism that Wegner referred to as 'chronic thought suppression', whereas compulsive patients are unable to inhibit their rituals. We tested 51 OCD patients using the Yale-Brown Obsessive Compulsive Scale (Y-BOCS), the White Bear Suppression Inventory (WBSI) and the Dysexecutive Questionnaire (DEX). Executive functions were tested using a cognitive test battery. We found that the total WBSI score was correlated with the Y-BOCS obsessive score but not with the Y-BOCS compulsive score. A stronger correlation was observed between the Y-BOCS obsessive score and the 'unwanted intrusive thoughts' factor based on Blumberg's 3-factor model of the WBSI. The total WBSI score was not correlated with the cognitive test results. The DEX score was significantly correlated with the Y-BOCS compulsive score; however, no correlation was found between the DEX score and the Y-BOCS obsessive score. A stronger correlation was observed between the Y-BOCS compulsive score and the 'inhibition' component of the DEX score, as defined by Burgess's 5-factor model. The DEX scores were correlated with cognitive test results measuring attention, cognitive flexibility and inhibitory processes. We conclude that obsessions indicate a failure of cognitive inhibition but do not involve significant impairment of executive functions, whereas compulsions indicate ineffective behavior inhibition and impaired executive functions.
执行功能障碍已被确定为强迫症(OCD)的潜在原因。强迫患者试图通过威格纳(Wegner)所谓的“慢性思维抑制”机制来抑制某些不必要的想法,而强迫患者则无法抑制其仪式。我们使用耶鲁-布朗强迫量表(Y-BOCS)、白熊抑制量表(WBSI)和执行功能障碍问卷(DEX)测试了 51 名 OCD 患者。使用认知测试组合测试执行功能。我们发现,总 WBSI 评分与 Y-BOCS 强迫评分相关,但与 Y-BOCS 强迫评分无关。在基于 Blumberg 的 WBSI 的三因素模型的基础上,WBSI 的“不想要的侵入性思维”因子与 Y-BOCS 强迫评分之间观察到更强的相关性。总 WBSI 评分与认知测试结果无关。DEX 评分与 Y-BOCS 强迫评分显著相关;然而,DEX 评分与 Y-BOCS 强迫评分之间没有相关性。在 Burgess 的五因素模型中,DEX 评分与“抑制”成分与 Y-BOCS 强迫评分之间观察到更强的相关性。DEX 评分与测量注意力、认知灵活性和抑制过程的认知测试结果相关。我们得出结论,强迫症表明认知抑制失败,但不涉及执行功能的重大损害,而强迫症则表明行为抑制无效和执行功能受损。