Nelson E, Stenzel P
Cancer. 1987 Oct 1;60(7):1567-9. doi: 10.1002/1097-0142(19871001)60:7<1567::aid-cncr2820600726>3.0.co;2-a.
This article is a report on the first known case of an intrapericardial yolk sac (endodermal sinus) tumor discovered in a 14-month-old girl. The patient presented with a systolic murmur, cardiomegaly, and manifestations of cardiac failure. At surgery a large, friable, intrapericardial mass with no evidence of extrapericardial spread was found. Histologic and immunohistochemical findings were diagnostic of yolk sac tumor. Following initial resection, chemotherapy, and a second resection 13 months after the first, the patient died 24 months after diagnosis. Tumor enlargement was associated with elevated serum alpha-fetoprotein levels.
本文报道了首例已知的发生于一名14个月大女童的心包内卵黄囊（内胚窦）瘤病例。该患者表现为收缩期杂音、心脏扩大及心力衰竭症状。手术中发现一个巨大、质脆的心包内肿物，无心包外扩散迹象。组织学和免疫组化检查结果确诊为卵黄囊瘤。首次切除术后进行了化疗，并在首次手术后13个月进行了二次切除，患者在诊断后24个月死亡。肿瘤增大与血清甲胎蛋白水平升高有关。
