CD1d 的表达在预后不良的慢性淋巴细胞白血病患者中更高。
CD1d expression is higher in chronic lymphocytic leukemia patients with unfavorable prognosis.
机构信息
Chair and Department of Clinical Immunology, Medical University of Lublin, Poland.
Department of Clinical Transplantology, Medical University of Lublin, Poland.
出版信息
Leuk Res. 2014 Apr;38(4):435-42. doi: 10.1016/j.leukres.2013.12.015. Epub 2013 Dec 25.
Through the analysis of CD1d expression by flow cytometry and qRT-PCR we showed lower CD1d molecule and CD1d mRNA expression in B cells of CLL patients than of healthy controls. The frequency of CD1d(+)/CD19(+) cells, CD1d staining intensity and CD1d transcript levels increased with the disease stage. CD1d expression was positively associated with ZAP-70 and CD38 expressions as well as with unfavourable cytogenetic changes. We established the relationship between high CD1d expression and shorter time to treatment and overall survival. We observed that CD1d expression in individual patients significantly changed over time. The percentage of CD1d(+)/CD19(+) cells inversely correlated with the percentage of iNKT cells.
通过流式细胞术和 qRT-PCR 分析 CD1d 的表达，我们发现 CLL 患者 B 细胞中的 CD1d 分子和 CD1d mRNA 表达低于健康对照组。CD1d(+) / CD19(+) 细胞的频率、CD1d 染色强度和 CD1d 转录水平随着疾病阶段的进展而增加。CD1d 表达与 ZAP-70 和 CD38 的表达以及不良细胞遗传学改变呈正相关。我们建立了高 CD1d 表达与治疗时间和总生存期较短之间的关系。我们观察到个别患者的 CD1d 表达随时间显著变化。CD1d(+) / CD19(+) 细胞的百分比与 iNKT 细胞的百分比呈负相关。
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