Broughton R J, Aguirre M
Electroencephalogr Clin Neurophysiol. 1987 Oct;67(4):317-26. doi: 10.1016/0013-4694(87)90117-9.
Differences between 'REM sleepiness' and 'NREM sleepiness' states in wakefulness studied respectively prior to REM-containing and NREM-only multiple sleep latency test (MSLT) naps were compared by complex evoked potentials (P300, CNV), subjective estimate (Stanford Sleepiness Scale, SSS) and MSLT measures in 12 untreated patients with narcolepsy-cataplexy. The EP paradigms lasted about 7 min each and were done during the 10 min immediately before MSLT naps at 10.00, 12.00, 14.00, 16.00 and 18.00 h. SSS forms were completed immediately before and after the EP studies and MSLT naps. Patients were studied on 2 days and performed either the P300 or CNV paradigm on each day. 'REM sleepiness' was found to be subjectively and objectively (shorter mean sleep latency on MSLT) greater. Although subjects were sleepier in REM sleepiness, the subsequent REM nap was relatively more refreshing and reduced SSS estimates to levels equivalent to those after NREM-only naps. EP measures also showed differences between the 2 sleepiness states. REM sleepiness was associated with a significantly larger P2 component (in both the P300 paradigm and the CNV paradigm), a strong but not significant trend towards reduced amplitude of the P3 component, and almost total suppression of the slow negative components of the CNV. REM sleepiness and NREM sleepiness therefore appear to be district and differentiable cerebral states.
在12例未经治疗的发作性睡病-猝倒症患者中，通过复合诱发电位（P300、CNV）、主观评估（斯坦福嗜睡量表，SSS）和多次睡眠潜伏期试验（MSLT）测量，比较了在含快速眼动（REM）睡眠和仅非快速眼动（NREM）睡眠的MSLT小睡之前分别研究的清醒状态下“REM嗜睡”和“NREM嗜睡”状态之间的差异。每次诱发电位（EP）范式持续约7分钟，在10:00、12:00、14:00、16:00和18:00进行MSLT小睡前的10分钟内完成。在EP研究和MSLT小睡前后立即完成SSS表格。患者在2天内接受研究，每天进行P300或CNV范式。发现“REM嗜睡”在主观和客观上（MSLT上的平均睡眠潜伏期更短）更严重。尽管受试者在REM嗜睡时更困倦，但随后的REM小睡相对更提神，并将SSS评估降低到与仅NREM小睡后相当的水平。EP测量也显示了两种嗜睡状态之间的差异。REM嗜睡与P2成分显著增大（在P300范式和CNV范式中均如此）、P3成分振幅降低的强烈但不显著趋势以及CNV的慢负成分几乎完全抑制有关。因此，REM嗜睡和NREM嗜睡似乎是不同且可区分的脑状态。
