Grassi F, Bouché M, Aguanno S, Molinaro M, Eusebi F
Exp Cell Res. 1987 Aug;171(2):498-502. doi: 10.1016/0014-4827(87)90181-9.
Acetylcholine receptor (AChR) was found to be present on the cell surface of the human rhabdomyoblast (RD) cell line. Two classes of ACh-activated channels have been observed, one with a large conductance and long duration and the other with smaller conductance and short duration, similar to those of human myotubes. RD membrane exhibited a specific binding to the alpha-bungarotoxin indicating the presence of nicotinic AChRs. These results support the hypothesis that rhabdomyosarcomas derive from myogenic precursors.
在人横纹肌母细胞（RD）细胞系的细胞表面发现了乙酰胆碱受体（AChR）。已观察到两类ACh激活通道，一类具有大电导和长持续时间，另一类具有较小电导和短持续时间，类似于人肌管的通道。RD细胞膜对α-银环蛇毒素表现出特异性结合，表明存在烟碱型AChR。这些结果支持横纹肌肉瘤源自肌源性前体细胞的假说。
