Am J Trop Med Hyg. 2014 Mar;90(3):530-534. doi: 10.4269/ajtmh.13-0655. Epub 2014 Jan 13.
Pregnant women bear the greatest burden of malaria-human immunodeficiency virus co-infection. Previous studies suggest that interaction with antiretroviral drugs may compromise antimalarial pharmacokinetics and treatment outcomes. We conducted a preliminary clinical study to assess quinine pharmacokinetics in Malian pregnant women with acute malaria who reported taking nevirapine-based antiretroviral therapy. Of seven women, six had stable concentrations of nevirapine in the plasma and one had none. Quinine concentrations were lower, and its metabolite 3-hydroxyquinine higher, in the six women with nevirapine than in the one without, and quinine concentrations were below the recommended therapeutic range in 50% of the women. This preliminary observation warrants further research to understand the impact of long-term antiretroviral therapy on the treatment of acute malaria.
孕妇是疟疾-人类免疫缺陷病毒合并感染的最大负担者。先前的研究表明，与抗逆转录病毒药物的相互作用可能会影响抗疟药的药代动力学和治疗效果。我们进行了一项初步的临床研究，以评估报告正在服用基于奈韦拉平的抗逆转录病毒疗法的马里急性疟疾孕妇的奎宁药代动力学。在 7 名妇女中，6 名妇女的血浆中奈韦拉平浓度稳定，1 名妇女没有奈韦拉平。有奈韦拉平的 6 名妇女的奎宁浓度较低，其代谢物 3-羟基奎宁较高，而没有奈韦拉平的 1 名妇女的奎宁浓度在推荐的治疗范围内。这一初步观察结果值得进一步研究，以了解长期抗逆转录病毒治疗对急性疟疾治疗的影响。
