Auten Ashley A, Beauchamp Lauren N, Hardinger Karen L
PharmD Candidate.
Clinical Associate Professor of Pharmacy Practice, University of Missouri-Kansas City.
Hosp Pharm. 2013 Jun;48(6):489-93. doi: 10.1310/hpj4806-489.
The interaction between grapefruit-containing beverages and immunosuppressants is not well defined in the literature. This study was conducted to investigate possible sources of grapefruit juice or grapefruit extract in common US-manufactured beverages. The goal was to identify those products that might serve as hidden sources of dietary grapefruit intake, increasing a transplant patient's risk for drug interactions.
A careful review of the ingredients of the 3 largest US beverage manufacturer's product lines was conducted through manufacturer correspondence, product labeling examination, and online nutrition database research. Focus was placed on citrus-flavored soft drinks, teas, and juice products and their impact on a patient's immunosuppressant regimens.
Twenty-three beverages were identified that contained grapefruit. Five did not contain the word "grapefruit" in the product name. In addition to the confirmed grapefruit-containing products, 17 products were identified as possibly containing grapefruit juice or grapefruit extract.
A greater emphasis should be placed upon properly educating patients regarding hidden sources of grapefruit in popular US beverages and the potential for food-drug interactions.
含葡萄柚的饮料与免疫抑制剂之间的相互作用在文献中尚无明确界定。本研究旨在调查美国常见生产饮料中葡萄柚汁或葡萄柚提取物的可能来源。目标是识别那些可能成为膳食中葡萄柚隐性摄入来源的产品,从而增加移植患者发生药物相互作用的风险。
通过与制造商通信、检查产品标签以及在线营养数据库研究,对美国三大饮料制造商产品线的成分进行了仔细审查。重点关注柑橘味软饮料、茶和果汁产品及其对患者免疫抑制方案的影响。
共识别出23种含葡萄柚的饮料。其中5种产品名称中未包含“葡萄柚”一词。除了已确认含葡萄柚的产品外,还识别出17种可能含有葡萄柚汁或葡萄柚提取物的产品。
应更加重视对患者进行适当教育,使其了解美国流行饮料中葡萄柚的隐性来源以及食物与药物相互作用的可能性。