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上颌后牙拔除术中利多卡因与阿替卡因等效剂量的比较:病例系列

A comparison of equivalent doses of lidocaine and articaine in maxillary posterior tooth extractions: case series.

作者信息

Friedl Christopher C, Bashutski Jill, Rashidi Navid

机构信息

Private Practice Fort Collins, Colorado USA.

Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan Ann Arbor, Michigan USA.

出版信息

J Oral Maxillofac Res. 2012 Jul 1;3(2):e4. doi: 10.5037/jomr.2012.3204. eCollection 2012.

Abstract

OBJECTIVES

Local anaesthesia is the standard of care during dental extractions. With the advent of newer local anesthetic agents, it is often difficult for the clinician to decide which agent would be most efficacious in a given clinical scenario. This study assessed the efficacy of equal-milligram doses of lidocaine and articaine in achieving surgical anaesthesia of maxillary posterior teeth diagnosed with irreversible pulpitis.

MATERIAL AND METHODS

This case-series evaluated a total of 41 patients diagnosed with irreversible pulpitis in a maxillary posterior tooth. Patients randomly received an infiltration of either 3.6 mL (72 mg) 2% lidocaine with 1:100,000 epinephrine or 1.8 mL (72 mg) 4% articaine with 1:100,000 epinephrine in the buccal fold and palatal soft tissue adjacent to the tooth. After 10 minutes, initial anaesthesia of the tooth was assessed by introducing a sterile 27-gauge needle into the gingival tissue adjacent to the tooth, followed by relief of the gingival cuff. Successful treatment was considered to have occurred when the tooth was extracted with no reported pain. Data was analyzed with the Fisher's exact test, unpaired t-test and normality test.

RESULTS

Twenty-one patients received lidocaine and 20 received articaine. Forty of the 41 patients achieved initial anaesthesia 10 minutes after injection: 21 after lidocaine and 19 after articaine (P = 0.488). Pain-free extraction was accomplished in 33 patients: 19 after lidocaine and 14 after articaine buccal and palatal infiltrations (P = 0.226).

CONCLUSIONS

There was no significant difference in efficacy between equivalent doses of lidocaine and articaine in the anaesthesia of maxillary posterior teeth with irreversible pulpitis.

摘要

目的

局部麻醉是拔牙时的标准治疗方法。随着新型局部麻醉剂的出现,临床医生往往难以决定在特定临床情况下哪种药物最有效。本研究评估了等量毫克剂量的利多卡因和阿替卡因在上颌后牙诊断为不可复性牙髓炎时实现手术麻醉的效果。

材料与方法

本病例系列评估了总共41例上颌后牙诊断为不可复性牙髓炎的患者。患者随机在患牙颊侧龈沟和腭侧软组织中注射3.6 mL(72 mg)2%利多卡因加1:100,000肾上腺素或1.8 mL(72 mg)4%阿替卡因加1:100,000肾上腺素进行浸润麻醉。10分钟后,通过将无菌27号针头插入患牙相邻的牙龈组织,然后松开牙龈袖口来评估患牙的初始麻醉情况。当拔牙时未报告疼痛,则认为治疗成功。数据采用Fisher精确检验、非配对t检验和正态性检验进行分析。

结果

21例患者接受了利多卡因治疗,20例接受了阿替卡因治疗。41例患者中有40例在注射后10分钟达到初始麻醉:利多卡因注射后21例,阿替卡因注射后19例(P = 0.488)。33例患者实现了无痛拔牙:利多卡因颊侧和腭侧浸润后19例,阿替卡因颊侧和腭侧浸润后14例(P = 0.226)。

结论

等量剂量的利多卡因和阿替卡因在上颌后牙不可复性牙髓炎麻醉中的效果无显著差异。

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