Bouwman Inge I, Kollen Boudewijn J, van der Meer Klaas, Nijman Rien J M, van der Heide Wouter K
Department of general practice, University of Groningen, University Medical Center Groningen, Antonius Deusinglaan 1, Groningen, AV 9713, Netherlands.
BMC Fam Pract. 2014 Jan 14;15:9. doi: 10.1186/1471-2296-15-9.
Although lower urinary tract symptoms (LUTS) seem to be related to cardiovascular disease (CVD) in men, it is unclear whether this relationship is unbiased. In order to investigate this relationship, we used longitudinal data for establishing the possible predictive value of LUTS for the development of CVD in a primary care population.
We performed a registry study using data from the Registration Network Groningen (RNG). All data from men aged 50 years and older during the study period from 1 January 1998 up to 31 December 2008 were collected. Cox proportional hazard regression analysis was used to determine the association between the proportions of CVD (outcome) and LUTS in our population.
Data from 6614 men were analysed. The prevalence of LUTS increased from 92/1000 personyears (py) in 1998 up to 183/1000 py in 2008. For cardiovascular diseases the prevalence increased from 176/1000 py in 1998 up to 340/1000 py in 2008. The incidence numbers were resp. 10.2/1000 py (1998) and 5.1/1000 py (2008) for LUTS, and 12.9/1000 py (1998) and 10.4/1000 py (2008) for CVD. Of all men, 23.2% reported CVD (41.1% in men with LUTS vs 19.5% in men without LUTS, p < 0.01). The hazard ratio of LUTS for cardiovascular events, compared to no LUTS, in the adjusted multivariate model, was 0.921(95% CI: 0.824 - 1.030; p = 0.150).
Based on the results, LUTS is not a factor that must be taken into account for the early detection of CVD in primary care.
尽管男性下尿路症状（LUTS）似乎与心血管疾病（CVD）有关，但尚不清楚这种关系是否存在偏差。为了研究这种关系，我们使用纵向数据来确定在初级保健人群中LUTS对CVD发生的可能预测价值。
我们使用来自格罗宁根注册网络（RNG）的数据进行了一项注册研究。收集了1998年1月1日至2008年12月31日研究期间所有50岁及以上男性的数据。采用Cox比例风险回归分析来确定我们人群中CVD（结局）比例与LUTS之间的关联。
分析了6614名男性的数据。LUTS的患病率从1998年的92/1000人年（py）增加到2008年的183/1000 py。心血管疾病的患病率从1998年的176/1000 py增加到2008年的340/1000 py。LUTS的发病率分别为1998年的10.2/1000 py和2008年的5.1/1000 py，CVD的发病率分别为1998年的12.9/1000 py和2008年 的10.4/1000 py。在所有男性中，23.2%报告患有CVD（LUTS男性中为41.1%，无LUTS男性中为19.5%，p<0.01）。在调整后的多变量模型中，与无LUTS相比，LUTS发生心血管事件的风险比为0.921（95%CI：0.824 - 1.030；p = 0.150）。
基于这些结果，LUTS不是初级保健中早期检测CVD时必须考虑的因素。
