Department of Urology and Andrology, Donauspital, Vienna, Austria.
Urology. 2011 Nov;78(5):1063-7. doi: 10.1016/j.urology.2011.05.065. Epub 2011 Sep 9.
To investigate the association between lower urinary tract symptoms (LUTS) and both coronary vascular disease (CVD) and stroke in men in a cross-sectional and longitudinal setting.
Men aged 30-92 years underwent a free health investigation and completed the International Prostate Symptom Score questionnaire. In the cross-sectional part, the 10-year CVD and stroke risks were estimated according to the Framingham risk score. In the follow-up period (mean 6.1 years) the CVD and stroke events were recorded.
Two-thousand ninety-two men aged 47.8 years (SD 11.5) were analyzed. No to mild LUTS were present in 1,738 men, 337 men had moderate LUTS, and 17 had severe LUTS. The 10-year risk (cross-sectional design) for CVD or stroke in men with no to mild, moderate, and severe LUTS was 8.8%, 10.6%, and 15.9% (P <.01) and 6.9%, 7.5%, and 11.7% (P <.01), respectively. Adjusted for age, diabetes, total and low-density lipoprotein cholesterol, the odds ratios for CVD and stroke risk were 0.98 (P = .58) and 0.99 (P = .72) for moderate and 1.28 (P = .03) and 1.66 (P <.01) for severe LUTS. During follow-up, 96 events (CVD or stroke) were recorded: Men with no to mild, moderate, and severe LUTS had 76 (4.4%), 15 (4.5%), and 5 (29.4%) events, respectively. The adjusted (see above) hazard ratios were 0.63 (P = .16) for moderate and 3.82 (P = .01) for severe LUTS.
Although moderate LUTS do not seem to be a risk factor for CVD and stroke, men with severe LUTS were at increased risk for both according to a cross-sectional and longitudinal analysis. Studies with a larger group of men with severe LUTS are warranted to further substantiate these observations.
在横断面和纵向研究中，探讨男性下尿路症状（LUTS）与冠状动脉疾病（CVD）和中风之间的关系。
年龄在 30-92 岁的男性接受了免费健康检查，并完成了国际前列腺症状评分问卷。在横断面部分，根据弗雷明汉风险评分估计了 10 年 CVD 和中风风险。在随访期间（平均 6.1 年）记录了 CVD 和中风事件。
共分析了 2092 名年龄为 47.8 岁（SD 11.5）的男性。1738 名男性无症状或轻度 LUTS，337 名男性中度 LUTS，17 名男性重度 LUTS。无症状或轻度、中度和重度 LUTS 的男性 10 年 CVD 或中风风险分别为 8.8%、10.6%和 15.9%（P<.01）和 6.9%、7.5%和 11.7%（P<.01）。调整年龄、糖尿病、总胆固醇和低密度脂蛋白胆固醇后，CVD 和中风风险的优势比分别为 0.98（P=.58）和 0.99（P=.72）（中度）和 1.28（P=.03）和 1.66（P<.01）（重度）。随访期间，记录了 96 例事件（CVD 或中风）：无症状或轻度、中度和重度 LUTS 的男性分别有 76（4.4%）、15（4.5%）和 5（29.4%）例事件。调整后的（如上所述）风险比分别为 0.63（P=.16）（中度）和 3.82（P=.01）（重度）。
尽管中度 LUTS 似乎不是 CVD 和中风的危险因素，但根据横断面和纵向分析，重度 LUTS 的男性患 CVD 和中风的风险增加。需要进行更多患有严重 LUTS 的男性的研究来进一步证实这些观察结果。
