Key Laboratory of Food Processing and Quality Control, College of Food Science and Technology, Nanjing Agricultural University, Nanjing 210095, PR China.
Key Laboratory of Food Processing and Quality Control, College of Food Science and Technology, Nanjing Agricultural University, Nanjing 210095, PR China.
Food Chem. 2014 May 15;151:101-9. doi: 10.1016/j.foodchem.2013.11.030. Epub 2013 Nov 16.
Two new noroleanane-type triterpene saponins, Salbige A (1) and Salbige B (2), have been isolated from the aerial parts of Salicornia herbacea together with five other known compounds, including echinocystic acid (3), gypsogenin (4), pheophorbide a (5), (13(2)S)-hydroxy-pheophorbide a (6) and (13(2)S)-hydro-pheophorbide-lactone a (7). The chemical structures of these compounds were elucidated by extensive spectroscopic analysis and on the basis of their chemical reactivity. This work represents the first recorded example of the isolation of these compounds from S. herbacea. Compounds 1 and 2 exhibited potent antiproliferative activities and high levels of selectivity towards A549 cancer cells, with IC50 values of 52.35 and 79.39 μM, respectively, whereas compound 5 showed high levels of inhibitory activity against A549 and HepG2 cancer cells with IC50 values of 6.15 and 17.56 μM, respectively. None of these compounds exhibited antioxidant activities except for compound 7, which showed weak antioxidant activity.
从盐角草的地上部分分离得到了两种新的诺罗烷型三萜皂苷，Salbige A（1）和 Salbige B（2），以及其他五种已知化合物，包括羽扇豆酸（3）、薯蓣皂苷元（4）、脱镁叶绿酸 a（5）、（13(2)S）-羟基脱镁叶绿酸 a（6）和（13(2)S）-脱镁叶绿酸-lactone a（7）。这些化合物的化学结构通过广泛的光谱分析和基于其化学反应性来阐明。这项工作代表了从盐角草中分离这些化合物的首例记录。化合物 1 和 2 表现出对 A549 癌细胞的强大增殖抑制活性和高选择性，IC50 值分别为 52.35 和 79.39 μM，而化合物 5 对 A549 和 HepG2 癌细胞具有高抑制活性，IC50 值分别为 6.15 和 17.56 μM。除了化合物 7 外，这些化合物均无抗氧化活性，而化合物 7 仅表现出较弱的抗氧化活性。
