Department of Medicine, McGill University, Montreal, Quebec.
Division of Nephrology, Department of Medicine, McMaster University, Hamilton.
Am J Kidney Dis. 2014 Mar;63(3):363-77. doi: 10.1053/j.ajkd.2013.12.001. Epub 2014 Jan 11.
The KDIGO (Kidney Disease: Improving Global Outcomes) clinical practice guideline for management of glomerulonephritis was recently released. The Canadian Society of Nephrology convened a working group to review the recommendations and comment on their relevancy and applicability to the Canadian context. A subgroup of adult nephrologists reviewed the guideline statements for management of glomerular disease in adults and agreed with most of the guideline statements developed by KDIGO. This commentary highlights areas for which there is lack of evidence and areas in need of translation of evidence into clinical practice. Areas of controversy or uncertainty, including the choice of second-line agents, are discussed in more detail. Existing practice variation also is addressed. The relevance of treatment recommendations to the Canadian practitioner is discussed.
KDIGO（肾脏疾病：改善全球预后）肾小球肾炎管理临床实践指南最近发布。加拿大肾脏病学会召集了一个工作组来审查这些建议，并就其相关性和对加拿大环境的适用性发表意见。一组成年肾病学家审查了成人肾小球疾病管理指南的声明，并同意 KDIGO 制定的大多数指南声明。本评论重点介绍了缺乏证据的领域和需要将证据转化为临床实践的领域。对存在争议或不确定性的领域，包括二线药物的选择，进行了更详细的讨论。还解决了现有的实践差异问题。讨论了治疗建议对加拿大从业者的相关性。
