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芪藤消浊颗粒对慢性肾小球肾炎大鼠环状RNA表达谱的影响

Effects of Qi Teng Xiao Zhuo granules on circRNA expression profiles in rats with chronic glomerulonephritis.

作者信息

Gao Jia-Rong, Jiang Nan-Nan, Jiang Hui, Wei Liang-Bing, Gao Ya-Chen, Qin Xiu-Juan, Zhu Meng-Qing, Wang Jing

机构信息

Department of Pharmacy, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, People's Republic of China.

College of Pharmacy, Anhui University of Chinese Medicine, Hefei, People's Republic of China.

出版信息

Drug Des Devel Ther. 2019 Jun 4;13:1901-1913. doi: 10.2147/DDDT.S191386. eCollection 2019.

DOI:10.2147/DDDT.S191386
PMID:31239641
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6556108/
Abstract

To screen and study circular RNA (circRNA) expression profiles in QTXZG-mediated treatment of chronic glomerulonephritis (CGN) induced by adriamycin in rats and to research the possible roles and molecular mechanisms of QTXZG. Next-generation RNA sequencing was used to identify circRNA expression profiles in CGN after QTXZG treatment compared with a CGN model group and a control group. Bioinformatics analysis was performed to predict potential target miRNAs and mRNAs. GO and pathway analyses for potential target mRNAs were used to explore the potential roles of differentially expressed (DE) circRNAs. We identified 31 and 21 significantly DE circRNAs between the model group vs the control group and the model group vs the QTXZG group, respectively. Four circRNAs that resulted from the establishment of the CGN model were reversed following treatment with QTXZG. Further analysis revealed that these four circRNAs may play important roles in the development of CGN. This study elucidated the comprehensive expression profile of circRNAs in CGN rats after QTXZG treatment for the first time. Analysis of the circRNA-miRNA-mRNA-ceRNA network to determine potential function provided a comprehensive understanding of circRNAs that may be involved in the development of CGN. The current study indicated that therapeutic effects of QTXZG on CGN may be due to regulation of circRNA expression.

摘要

筛选并研究芪桃血尿胶囊（QTXZG）对阿霉素诱导的大鼠慢性肾小球肾炎（CGN）治疗中的环状RNA（circRNA）表达谱，并探究QTXZG可能的作用及分子机制。采用新一代RNA测序技术，与CGN模型组和对照组比较，鉴定QTXZG治疗后CGN中的circRNA表达谱。进行生物信息学分析以预测潜在的靶标微小RNA（miRNA）和信使核糖核酸（mRNA）。对潜在靶标mRNA进行基因本体（GO）和通路分析，以探索差异表达（DE）circRNA的潜在作用。我们分别在模型组与对照组、模型组与QTXZG组之间鉴定出31个和21个显著差异表达的circRNA。CGN模型建立后产生的4个circRNA在用QTXZG治疗后表达逆转。进一步分析表明，这4个circRNA可能在CGN的发生发展中起重要作用。本研究首次阐明了QTXZG治疗后CGN大鼠中circRNA的综合表达谱。对circRNA- miRNA-mRNA-竞争性内源RNA（ceRNA）网络进行分析以确定潜在功能，有助于全面了解可能参与CGN发生发展的circRNA。当前研究表明，QTXZG对CGN的治疗作用可能归因于对circRNA表达的调控。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b5f/6556108/b510b73b0b52/DDDT-13-1901-g0010.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b5f/6556108/a6b572acbf7a/DDDT-13-1901-g0002.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b5f/6556108/53a84b417d73/DDDT-13-1901-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b5f/6556108/c654b31909d0/DDDT-13-1901-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b5f/6556108/a99f774fd2e2/DDDT-13-1901-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b5f/6556108/127e5688bf0f/DDDT-13-1901-g0008.jpg
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