[稳定期慢性阻塞性肺疾病患者运动试验中摄氧效率与运动能力的相关性]

[Association of oxygen uptake efficiency in exercise test with exercise capacity in patients with stable chronic obstructive pulmonary disease].

作者信息

Wu Chang-wei, Liu Jin-ming, Yang Wen-lan, Sun Xing-guo, Huang Dan-dan, Liu Hai-jian, Chen Shu-juan

机构信息

The Medical College of Soochow University, Suzhou 215006, China.

Department of Respiratory Medicine, Shanghai Pulmonary Hospital affiliated to Tongji University, Shanghai 200433, China, Email:

出版信息

Zhonghua Jie He He Hu Xi Za Zhi. 2013 Sep;36(9):661-6.

PMID:24423819

Abstract

OBJECTIVE

To explore the characteristics of oxygen uptake efficiency (OUE) in patients with chronic obstructive pulmonary disease (COPD), and to analyze the relationship between OUE and the exercise capacity.

METHODS

Pulmonary function test and cardiopulmonary exercise test were performed in 59 patients with stable COPD (grade I, n = 15; grade II, n = 16; grade III, n = 19; grade IV, n = 9) and 29 healthy volunteers of the same age. Their successive breathing respiratory exchange parameters were collected and analyzed. t test and χ(2) test were used for 2 sample comparison, while multiple comparisons among groups were performed by using single factor analysis of variance. Correlation analysis was done by Pearson correlation test.

RESULTS

Compared with the normal control group [(2.2 ± 0.4) L·min(-1)·lg(L·min(-1))(-1); (35 ± 4) ml/L], the OUES and OUEP of the COPD patient group [(1.9 ± 0.3) L·min(-1)·lg(L·min(-1))(-1); (31 ± 5) ml/L]were significantly lower (t = 4.57, 3.39, all P < 0.01) . The OUE of the grade I patients showed no significant difference compared with the normal control group (t = 0.36-1.49, all P > 0.05), while the OUES of the grade II-IV patients [(2.05 ± 0.26), (1.76 ± 0.28) and (1.63 ± 0.19) L·min(-1)·lg(L·min(-1))(-1)] decreased significantly compared to the normal control group [(2.23 ± 0.39) L·min(-1)·lg(L·min(-1))(-1); t = 2.42-5.26, all P < 0.05]. The OUEP and the OUE at the anaerobic threshold of the grade II-III patients [(31 ± 4) and (31 ± 5), (29 ± 5) and (29 ± 5) ml/L] decreased significantly compared to the normal control group [(35 ± 4) and (34 ± 4) ml/L, t = 2.18-4.83, all P < 0.05]. The OUES, OUEP and the OUE at the anaerobic threshold in COPD patients were correlated (r = 0.500-0.625, all P < 0.01) positively with the exercise tolerance (peak VO2% pred).

CONCLUSIONS

The oxygen uptake efficiency of patients with COPD is significantly reduced compared to that of the normal subjects, and is correlated positively with the exercise capacity.

摘要

目的

探讨慢性阻塞性肺疾病（COPD）患者摄氧效率（OUE）的特点，并分析OUE与运动能力之间的关系。

方法

对59例稳定期COPD患者（Ⅰ级，n = 15；Ⅱ级，n = 16；Ⅲ级，n = 19；Ⅳ级，n = 9）和29名同年龄健康志愿者进行肺功能测试和心肺运动试验。收集并分析他们连续呼吸的呼吸交换参数。两组样本比较采用t检验和χ²检验，组间多重比较采用单因素方差分析。相关性分析采用Pearson相关检验。

结果

与正常对照组[（2.2 ± 0.4）L·min⁻¹·lg（L·min⁻¹）⁻¹；（35 ± 4）ml/L]相比，COPD患者组的OUES和OUEP[（1.9 ± 0.3）L·min⁻¹·lg（L·min⁻¹）⁻¹；（31 ± 5）ml/L]显著降低（t = 4.57，3.39，P均< 0.01）。Ⅰ级患者的OUE与正常对照组相比无显著差异（t = 0.36 - 1.49，P均> 0.05），而Ⅱ - Ⅳ级患者的OUES[（2.05 ± 0.26）、（1.76 ± 0.28）和（1.63 ± 0.19）L·min⁻¹·lg（L·min⁻¹）⁻¹]与正常对照组[（2.23 ± 0.39）L·min⁻¹·lg（L·min⁻¹）⁻¹]相比显著降低（t = 2.42 - 5.26，P均< 0.05）。Ⅱ - Ⅲ级患者的OUEP和无氧阈时的OUE[（31 ± 4）和（31 ± 5）、（29 ± 5）和（29 ± 5）ml/L]与正常对照组[（35 ± 4）和（34 ± 4）ml/L]相比显著降低（t = 2.18 - 4.83，P均< 0.05）。COPD患者的OUES、OUEP和无氧阈时的OUE与运动耐力（预计峰值VO₂%）呈正相关（r = 0.500 - 0.625，P均< 0.01）。