Yu Xin-yang, Zhang Hua
Department of Obstetrics & Gynecology, First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China.
Department of Obstetrics & Gynecology, First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China. Email:
Zhonghua Yi Xue Za Zhi. 2013 Nov 19;93(43):3450-3.
To explore the effects of nutritional liquid supplement designed for diabetes mellitus on postprandial glucose state and pregnancy outcomes in patients with gestational diabetes mellitus (GDM).
A total of 69 cases of pregnant GDM women at Department of Obstetrics & Gynecology, First Affiliated Hospital, Chongqing Medical University from October 2011 to January 2012 were randomized into the intervention and control groups. But only 31 cases in intervention group finished the study versus 29 cases in control group. The inter-group differences were analyzed for general clinical profiles before intervention, 2-hour postprandial blood glucose levels and pregnancy outcomes, etc. The General Linear Model Repeated Measures process was used to analyze the variance of 2-hour postprandial blood glucose data. And the Mauchy's test of sphericity was employed to determine the correlation.
(1) No significant difference in general clinical profiles before intervention between intervention and control groups (P > 0.05). (2) The mean values of 2-hour postprandial blood glucose were as follows: intervention group (mmol/L) : 6.2 ± 0.7(1w), 5.9 ± 0.5(2w), 5.7 ± 0.5(3w), 5.8 ± 0.6 (4w), 5.7 ± 0.5(5w), 5.7 ± 0.4(6w), 5.9 ± 0.3(7w), 6.0 ± 0.4(8w), 6.0 ± 0.5(9w); control group: 6.7 ± 0.3 (1w), 6.2 ± 0.4(2w), 6.2 ± 0.5(3w), 6.2 ± 0.4(4w), 6.1 ± 0.4(5w), 6.0 ± 0.3 (6w), 5.8 ± 0.4 (7w), 6.1 ± 0.4 (8w), 6.1 ± 0.4(9w). The results of Mauchy's test of sphericity indicated that the blood glucose level of the intervention group was significantly lower than that of the control group (P < 0.01). (3) The incidence of premature rupture of membranes and polyhydramnios, rate of neonatal pneumonia, weight of newborn and pregnancy women and level of glycosylated hemoglobin in intervention group were significantly lower than those in control group (P < 0.05).
Compared with common diet, after using nutritional supplement, the postprandial blood glucose level is significantly reduced and the pregnancy outcomes also improved in GDM patients.
探讨糖尿病专用营养液体补充剂对妊娠期糖尿病（GDM）患者餐后血糖状态及妊娠结局的影响。
选取2011年10月至2012年1月在重庆医科大学附属第一医院妇产科就诊的69例妊娠GDM患者，随机分为干预组和对照组。但干预组仅31例完成研究，对照组29例完成研究。分析干预前两组的一般临床资料、餐后2小时血糖水平及妊娠结局等组间差异。采用一般线性模型重复测量过程分析餐后2小时血糖数据的方差，并采用Mauchy球形检验确定相关性。
（1）干预组和对照组干预前一般临床资料无显著差异（P>0.05）。（2）餐后2小时血糖平均值如下：干预组（mmol/L）：6.2±0.7（1周），5.9±0.5（2周），5.7±0.5（3周），5.8±0.6（4周），5.7±0.5（5周），5.7±0.4（6周），5.9±0.3（7周），6.0±0.4（8周），6.0±0.5（9周）；对照组：6.7±0.3（1周），6.2±0.4（2周），6.2±0.5（3周），6.2±0.4（4周），6.1±0.4（5周），6.0±0.3（6周），5.8±0.4（7周），6.1±0.4（8周），6.1±0.4（9周）。Mauchy球形检验结果表明，干预组血糖水平显著低于对照组（P<0.01）。（3）干预组胎膜早破、羊水过多发生率、新生儿肺炎发生率、新生儿及孕妇体重、糖化血红蛋白水平均显著低于对照组（P<0.
