Comparative Genomics Unit, CSIR-Institute of Genomics and Integrative Biology, Delhi University Campus, Mall Road, Delhi, 110007 India.
Division of Radiation Biotechnology, Institute of Nuclear Medicine and Allied Sciences (INMAS), DRDO, Timarpur, Delhi, 110007 India.
Indian J Microbiol. 2013 Jun;53(2):130-6. doi: 10.1007/s12088-013-0369-0. Epub 2013 Feb 12.
A gram positive, extreme haloalkaliphilic, radioresistant bacterium was isolated from mangrove region of Kerala (India) which was characterized as Exiguobacterium sp. HKG-126 using morphological, physiological, biochemical and molecular characterization. Present investigation was undertaken to examine Exiguobacterium sp. as a potential source of broad-spectrum antimicrobial activity and enhancement in this activity was observed due to cross-species/cross-genera induction and also in response to high dose of gamma (γ) irradiation. Individual studies on the antimicrobial activity of all the co-cultivated bacterial strains before and after mixed culture fermentation, showed excellent enhancement in antimicrobial activity of Exiguobacterium sp. against a variety of clinical pathogens. To the best of our knowledge, this is the first report showing existence of an extremely high radioresistant strain of (up to 15 kGy) Exiguobacterium sp.
从印度喀拉拉邦的红树林地区分离到一株革兰氏阳性、极端嗜盐嗜碱、抗辐射的细菌,通过形态学、生理学、生物化学和分子特征鉴定,将其鉴定为极端嗜盐菌属 HKG-126。本研究旨在探讨极端嗜盐菌属作为广谱抗菌活性的潜在来源,并观察到由于种间/属间诱导以及高剂量γ(γ)辐射,其活性增强。对混合培养发酵前后所有共培养细菌菌株的抗菌活性进行的单独研究表明,极端嗜盐菌属对各种临床病原体的抗菌活性得到了极好的增强。据我们所知,这是第一份报道显示存在一种具有极高抗辐射能力(高达 15 kGy)的极端嗜盐菌属菌株的报告。