严重的全身感染掩盖了潜在的儿童白血病。
Severe systemic infection masking underlying childhood leukemia.
作者信息
Rajendran Aruna, Trehan Amita, Ahluwalia Jasmina, Marwaha Ram Kumar
机构信息
Pediatric Hematology Oncology unit, Department of Pediatrics, Advanced Pediatrics Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012 India.
Department of Hematology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
出版信息
Indian J Hematol Blood Transfus. 2013 Sep;29(3):167-70. doi: 10.1007/s12288-012-0166-7. Epub 2012 Jul 25.
Abstract
Severe childhood infections can occasionally be accompanied by bone marrow suppression. It is unusual for infection induced marrow aplasia to evolve into acute leukemia. We share our experience in managing four children with severe sepsis and pancytopenia which in due course evolved into acute leukemia. This report emphasizes that sepsis related pancytopenia can be a harbinger of evolving hematopoietic disorders.
摘要
严重的儿童感染偶尔会伴有骨髓抑制。感染所致的骨髓再生障碍演变为急性白血病的情况并不常见。我们分享了对四名患有严重脓毒症和全血细胞减少症儿童的治疗经验，这些儿童在病程中均演变为急性白血病。本报告强调，脓毒症相关的全血细胞减少症可能是造血系统疾病演变的先兆。
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本文引用的文献
1
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Autoimmun Rev. 2009 Sep;9(1):11-6. doi: 10.1016/j.autrev.2009.02.032. Epub 2009 Feb 24.
2
Hematologic and molecular spontaneous remission following sepsis in acute monoblastic leukemia with translocation (9;11): a case report and review of the literature.伴有易位（9；11）的急性单核细胞白血病败血症后血液学和分子学自发缓解：一例报告并文献复习
Eur J Haematol. 2004 Jul;73(1):62-6. doi: 10.1111/j.1600-0609.2004.00248.x.
3
Transient pancytopenia preceding acute lymphoblastic leukaemia (pre-ALL) precipitated by parvovirus B19.由细小病毒B19引发的急性淋巴细胞白血病（ALL前期）之前的短暂全血细胞减少症。
Br J Haematol. 2001 Sep;114(4):810-3. doi: 10.1046/j.1365-2141.2001.03021.x.
4
Spontaneous remission in a secondary acute myelogenous leukaemia following invasive pulmonary aspergillosis.侵袭性肺曲霉病继发急性髓系白血病后的自发缓解
Ann Hematol. 2001 Jul;80(7):423-5. doi: 10.1007/s002770100300.
5
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Am J Hematol. 1997 Sep;56(1):42-4. doi: 10.1002/(sici)1096-8652(199709)56:1<42::aid-ajh9>3.0.co;2-2.
6
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Cancer Treat Rev. 1996 Nov;22(6):395-423. doi: 10.1016/s0305-7372(96)90023-7.
7
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Br J Haematol. 1994 Aug;87(4):879-80. doi: 10.1111/j.1365-2141.1994.tb06761.x.
8
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Br J Haematol. 1981 Nov;49(3):387-93. doi: 10.1111/j.1365-2141.1981.tb07241.x.
9
Spontaneous remission of acute myeloid leukemia in a patient with concurrent Pneumocystis carinii pneumonia.
Nouv Rev Fr Hematol (1978). 1991;33(5):363-4.
10
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