Tzankov A, Ludescher C, Duba H C, Steinlechner M, Knapp R, Schmid T, Grünewald K, Gastl G, Stauder R
Institute of Pathology, Innsbruck, Austria.
Ann Hematol. 2001 Jul;80(7):423-5. doi: 10.1007/s002770100300.
Spontaneous remission of adult acute myelogenous leukaemia (AML) represents a rare event. We report a 60-year-old female patient suffering from secondary AML M1 and severe invasive pulmonary hyalohyphomycosis highly suggestive of aspergillosis. Two months after the diagnosis of leukaemia, she achieved a spontaneous remission lasting 3 months, although neither cytostatic drugs nor corticoids were administered because of a septic condition. At the time of remission, a chronic hepatitis C virus infection and a polyclonal hypergammaglobulinaemia were present, and the patient received granulocyte colony-stimulating factor once. This report represents the first documentation of a spontaneous remission in AML following invasive pulmonary hyalohyphomycosis. Possible mechanisms of this phenomenon are discussed.
成人急性髓系白血病（AML）的自发缓解是一种罕见事件。我们报告一名60岁女性患者，患有继发性AML M1以及高度提示曲霉菌病的严重侵袭性肺透明丝孢霉病。白血病诊断后两个月，她实现了持续3个月的自发缓解，尽管由于脓毒症未给予细胞毒性药物或皮质类固醇。缓解期时，患者存在慢性丙型肝炎病毒感染和多克隆高球蛋白血症，且仅接受过一次粒细胞集落刺激因子治疗。本报告是侵袭性肺透明丝孢霉病后AML自发缓解的首例记录。文中讨论了这一现象可能的机制。
