Nori D, Hilaris B S, Martini N
Surg Clin North Am. 1987 Oct;67(5):1093-102. doi: 10.1016/s0039-6109(16)44347-1.
Endobronchial tumors present a difficult therapeutic problem. Most often these patients have primary lung cancer and present with endobronchial disease following a definitive course of surgery and/or irradiation. The most common methods of treatment include transbronchial excision of tumor or laser coagulation. The improvement obtained from these procedures is usually limited to 2 or 3 months, and repeated treatments become more difficult and less effective. A number of brachytherapy radiation techniques have been developed to deliver localized radiation in higher doses without exceeding surrounding normal tissue tolerance. Intraluminal radiation with brachytherapy techniques consists of implantation of radioactive pellets into the tumor through a rigid or flexible bronchoscope or the use of afterloading removable implants with remote afterloading techniques. These procedures can be combined with laser therapy to obtain effective palliation and long-term tumor control. Initial results appear promising.
支气管内肿瘤带来了棘手的治疗难题。这些患者大多患有原发性肺癌，在经历了明确的手术和/或放疗疗程后出现支气管内病变。最常见的治疗方法包括经支气管肿瘤切除术或激光凝固术。这些治疗方法所带来的改善通常仅持续2至3个月，而且重复治疗会变得更加困难且效果更差。已经研发出多种近距离放射治疗技术，以便在不超过周围正常组织耐受剂量的情况下，给予更高剂量的局部放射治疗。采用近距离放射治疗技术的腔内放射治疗包括通过硬质或可弯曲支气管镜将放射性颗粒植入肿瘤，或使用后装可移除植入物及远程后装技术。这些治疗方法可与激光治疗相结合，以实现有效的姑息治疗和长期的肿瘤控制。初步结果看起来很有前景。
