亚急性硬化性全脑炎中局部脑葡萄糖代谢率及脑脊液单胺代谢产物
Regional cerebral metabolic rate for glucose and cerebrospinal fluid monoamine metabolites in subacute sclerosing panencephalitis.
作者信息
Yanai K, Miyabayashi S, Iinuma K, Tada K, Fukuda H, Ito M, Matsuzawa T
出版信息
Tohoku J Exp Med. 1987 Jun;152(2):103-9. doi: 10.1620/tjem.152.103.
Regional cerebral metabolic rate for glucose (rCMRglu) and cerebrospinal fluid monoamine metabolites were measured in two cases of subacute sclerosing panencephalitis (SSPE) with different clinical courses. A marked decrease in rCMRglu was found in the cortical gray matter of a patient with rapidly developing SSPE (3.6-4.2 mg/100 g brain tissue/min). However, the rCMRglu was preserved in the caudate and lenticular nuclei of the patient (7.7 mg/100 g/min). The rCMRglu in a patient with slowly developing SSPE revealed patterns and values similar to those of the control. Cerebrospinal fluid monoamine metabolites; homovanilic acid and 5-hydroxyindoleacetic acid, were decreased in both rapidly and slowly developing SSPE. These data indicated that rCMRglu correlated better with the neurological and psychological status and that dopaminergic and serotonergic abnormalities have been implicated in pathophysiology of SSPE.
对两例具有不同临床病程的亚急性硬化性全脑炎（SSPE）患者测量了局部脑葡萄糖代谢率（rCMRglu）和脑脊液单胺代谢产物。在一名快速进展型SSPE患者的皮质灰质中发现rCMRglu显著降低（3.6 - 4.2毫克/100克脑组织/分钟）。然而，该患者的尾状核和豆状核中的rCMRglu得以保留（7.7毫克/100克/分钟）。一名缓慢进展型SSPE患者的rCMRglu显示出与对照组相似的模式和数值。在快速进展型和缓慢进展型SSPE中，脑脊液单胺代谢产物高香草酸和5 - 羟吲哚乙酸均降低。这些数据表明，rCMRglu与神经和心理状态的相关性更好，并且多巴胺能和5 - 羟色胺能异常与SSPE的病理生理学有关。
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