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Studies on the efficacy of DL-alpha-difluoromethylornithine (DFMO) associated with bleomycin and suramin for treatment of mice infected with metacyclic forms of Trypanosoma brucei brucei.

作者信息

Demey F

出版信息

Vet Res Commun. 1987;11(3):271-4. doi: 10.1007/BF00570924.

DOI:10.1007/BF00570924
PMID:2442883
Abstract

NMRI mice were treated with DFMO-bleomycin and DFMO-suramin drug combinations at day 8 post-inoculation. The highest percentage of parasitologically non patent mice were attained with DFMO-suramin combination treatments. Parasitological and serological examinations of the non-relapsing mice strongly suggests trypanosome clearance.

摘要

相似文献

1
Studies on the efficacy of DL-alpha-difluoromethylornithine (DFMO) associated with bleomycin and suramin for treatment of mice infected with metacyclic forms of Trypanosoma brucei brucei.
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2
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本文引用的文献

1
Experimental infection with two stocks of Trypanosoma brucei gambiense. Study of the evolution by elution techniques of tissues.
Contrib Microbiol Immunol. 1983;7:120-9.
2
Polyamine metabolism: a potential therapeutic target in trypanosomes.多胺代谢：锥虫潜在的治疗靶点。
Science. 1980 Oct 17;210(4467):332-4. doi: 10.1126/science.6775372.
3
New drug combination for experimental late-stage African trypanosomiasis: DL-alpha-difluoromethylornithine (DFMO) with suramin.用于实验性晚期非洲锥虫病的新药组合：DL-α-二氟甲基鸟氨酸（DFMO）与苏拉明。
Am J Trop Med Hyg. 1984 Nov;33(6):1073-7. doi: 10.4269/ajtmh.1984.33.1073.
4
Efficacy of combinations of difluoromethylornithine and bleomycin in a mouse model of central nervous system African trypanosomiasis.二氟甲基鸟氨酸与博来霉素联合用药在中枢神经系统非洲锥虫病小鼠模型中的疗效
Proc Natl Acad Sci U S A. 1983 Sep;80(18):5729-33. doi: 10.1073/pnas.80.18.5729.
5
The haematocrit centrifuge technique for the diagnosis of African trypanosomiasis.用于诊断非洲锥虫病的血细胞比容离心技术。
Acta Trop. 1970;27(4):384-6.
6
Trypanosoma brucei: a rapid "matching" method for estimating the host's parasitemia.布氏锥虫：一种估算宿主寄生虫血症的快速“匹配”方法。
Exp Parasitol. 1976 Dec;40(3):427-31. doi: 10.1016/0014-4894(76)90110-7.