Jennings F W, Ulrich P, Cerami A
Department of Veterinary Parasitology, University of Glasgow, UK.
Trop Med Parasitol. 1987 Sep;38(3):181-6.
The efficacy of 1,3,5-triacetylbenzene tris(guanylhydrazone) trihydrochloride i.e. [(TBG)] in the treatment of early and late stage infections of Trypanosoma brucei in mice was investigated. Successful treatment on day 3 after infection could be achieved by doses of 2 X 2.5 mg kg-1. If treatment was delayed to 21 days after infection then the mice had to be given either suramin (1 X 20 mg kg-1) or difluoromethyl-ornithine (DFMO) 2% solution for 14 days in addition to either 15 mg kg-1 (TBG) daily for 4 days or 10 mg kg-1 twice daily for 4 days to obtain permanent cures. Other guanylhydrazone compounds were investigated for the treatment of chronic T. brucei infections and, at the limited dose levels used, failed to give any permanent cures. The use of (TBG) in the treatment of early and late stage infections of T. congolense and T. evansi indicated that treatment on day 3 after infection could be successful but on day 21 after infection the results were disappointing.
研究了1,3,5 - 三乙酰苯三（胍基腙）三盐酸盐即[(TBG)]对小鼠布氏锥虫早期和晚期感染的治疗效果。感染后第3天，剂量为2×2.5mg/kg - 1可成功治愈。如果治疗延迟到感染后21天，那么除了每天给予15mg/kg - 1（TBG），连续4天，或每天两次给予10mg/kg - 1，连续4天外，小鼠还必须给予苏拉明（1×20mg/kg - 1）或2%二氟甲基鸟氨酸（DFMO）溶液，持续14天才能获得永久性治愈。研究了其他胍基腙化合物对慢性布氏锥虫感染的治疗效果，在所使用的有限剂量水平下，未能实现任何永久性治愈。使用(TBG)治疗刚果锥虫和伊氏锥虫的早期和晚期感染表明，感染后第3天治疗可能成功，但感染后第21天结果令人失望。
