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甲氨蝶呤治疗银屑病关节炎。

Methotrexate treatment of psoriatic arthritis.

作者信息

Zachariae H, Zachariae E

出版信息

Acta Derm Venereol. 1987;67(3):270-3.

PMID:2442947
Abstract

A prospective study was carried out over 12 months involving twenty-eight patients with psoriatic arthritis. Almost all patients improved dramatically with regard to both pain and function. Clinical assessment including evaluation of number of swollen joints, joint tenderness score, and morning stiffness was performed by external observer without any knowledge of previous evaluation data. These data together with patients' assessment of pain and assessment of general condition, consumption of analgetics, and sedimentation rate improved significantly after three and six or twelve months. Apart from transient increases in serum transaminases no other abnormalities developed during the study.

摘要

一项为期12个月的前瞻性研究纳入了28例银屑病关节炎患者。几乎所有患者在疼痛和功能方面都有显著改善。临床评估包括对肿胀关节数量、关节压痛评分和晨僵的评估,由外部观察者进行,其对先前的评估数据一无所知。这些数据与患者对疼痛的评估、总体状况评估、镇痛药使用情况以及血沉在3个月、6个月或12个月后均有显著改善。除血清转氨酶短暂升高外,研究期间未出现其他异常情况。

相似文献

1
Methotrexate treatment of psoriatic arthritis.甲氨蝶呤治疗银屑病关节炎。
Acta Derm Venereol. 1987;67(3):270-3.
2
Cyclosporine in the treatment of psoriatic arthritis.环孢素治疗银屑病关节炎
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[Experience with long term low dose methotrexate treatment in rheumatoid arthritis and arthritic psoriasis].[长期低剂量甲氨蝶呤治疗类风湿关节炎和关节炎型银屑病的经验]
Orv Hetil. 1995 Jul 16;136(29):1555-7.
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Low-dose weekly oral methotrexate therapy for inflammatory arthritis.低剂量每周口服甲氨蝶呤治疗炎性关节炎。
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Methotrexate in psoriatic arthritis: a retrospective study.甲氨蝶呤治疗银屑病关节炎:一项回顾性研究。
Acta Derm Venereol. 1983;63(2):165-7.
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Caffeine consumption and methotrexate dosing requirement in psoriasis and psoriatic arthritis.银屑病和银屑病关节炎患者的咖啡因摄入量与甲氨蝶呤给药需求
Int J Dermatol. 2007 Feb;46(2):157-9. doi: 10.1111/j.1365-4632.2006.02954.x.
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[Blood cell concentration of methotrexate in long-term therapy of inflammatory rheumatic diseases].[甲氨蝶呤在炎症性风湿性疾病长期治疗中的血细胞浓度]
Acta Med Austriaca. 1988;15(5):140-4.
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[Alpha 1-fetoprotein--a marker of potential PUVA side-effects in psoriasis?].
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Self-assessment of disease activity by patients with rheumatoid arthritis.类风湿关节炎患者对疾病活动度的自我评估。
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引用本文的文献

1
Real-life experience of using conventional disease-modifying anti-rheumatic drugs (DMARDs) in psoriatic arthritis (PsA). Retrospective analysis of the efficacy of methotrexate, sulfasalazine, and leflunomide in PsA in comparison to spondyloarthritides other than PsA and literature review of the use of conventional DMARDs in PsA.在银屑病关节炎(PsA)中使用传统改善病情抗风湿药(DMARDs)的实际经验。回顾性分析甲氨蝶呤、柳氮磺胺吡啶和来氟米特在PsA中的疗效,并与除PsA之外的脊柱关节炎进行比较,同时对传统DMARDs在PsA中的应用进行文献综述。
Eur J Rheumatol. 2017 Mar;4(1):1-10. doi: 10.5152/eurjrheum.2017.1608. Epub 2017 Mar 1.
2
A randomised, double blind, placebo controlled, multicentre trial of combination therapy with methotrexate plus ciclosporin in patients with active psoriatic arthritis.一项针对活动性银屑病关节炎患者的甲氨蝶呤联合环孢素联合治疗的随机、双盲、安慰剂对照、多中心试验。
Ann Rheum Dis. 2005 Jun;64(6):859-64. doi: 10.1136/ard.2004.024463. Epub 2004 Nov 4.
3
Diagnosis and management of psoriatic arthritis.银屑病关节炎的诊断与管理
Drugs. 2002;62(17):2447-57. doi: 10.2165/00003495-200262170-00004.
4
Spondylarthropathies: options for combination therapy.脊柱关节病:联合治疗的选择
Springer Semin Immunopathol. 2001;23(1-2):147-63. doi: 10.1007/s002810100064.