Kragballe K, Zachariae E, Zachariae H
Acta Derm Venereol. 1983;63(2):165-7.
The response of psoriatic arthritis to methotrexate was evaluated retrospectively in 59 consecutive patients. Initially almost all received 15 mg weekly. When clinical improvement occurred, the dose was gradually reduced. In 7 patients methotrexate had to be discontinued within a year due to adverse reactions. The remaining 52 patients were treated from 1 to 11 years, median 3 years. Among these a modest improvement was seen in 21, while in 22 the signs of inflammatory joint disease almost disappeared. The favourable response was related to the short duration of arthritis, but unrelated to the severity of the disease.
对59例连续性银屑病关节炎患者使用甲氨蝶呤的反应进行了回顾性评估。最初，几乎所有患者每周服用15毫克。当出现临床改善时，剂量逐渐减少。7例患者因不良反应在1年内不得不停用甲氨蝶呤。其余52例患者接受治疗1至11年，中位数为3年。其中21例有一定程度改善，22例炎症性关节病体征几乎消失。良好反应与关节炎病程短有关，但与疾病严重程度无关。
