全身炎症反应综合征中的细胞因子：综述
Cytokines in the systemic inflammatory response syndrome: a review.
作者信息
Jaffer U, Wade R G, Gourlay T
机构信息
Hammersmith Hospital, London, UK.
出版信息
HSR Proc Intensive Care Cardiovasc Anesth. 2010;2(3):161-75.
INTRODUCTION
Patients subject to major surgery, suffering sepsis, major trauma, or following cardiopulmonary bypass exhibit a systemic inflammatory response. This inflammatory response involves a complex array of inflammatory polypeptide molecules known as cytokines. It is well accepted that the loss of local control of the release of these cytokines leads to systemic inflammation and potentially deleterious consequences including the Systemic Inflammatory Response Syndrome, Multi-Organ Dysfunction Syndrome, shock and death.
METHODS
The Medline database was searched for literature on mechanisms involved in the development of SIRS and potential targets for modifying the inflammatory response. We focus on the novel therapy of cytokine adsorption as a promising removal technology.
RESULTS
Accumulating data from human studies and experimental animal models suggests that both pro- and anti- inflammatory cytokines are released following a variety of initiating stimuli including endotoxin release, complement activation, ischaemia reperfusion injury and others.
DISCUSSION
Pro-and anti-inflammatory cytokines interact in a complex and unpredictable manner to influence the immune system and eventually cause multiple end organ effects. Cytokine adsorption therapy provides a potential solution to improving outcomes following Systemic Inflammatory Response Syndrome.
引言
接受大手术、患有败血症、遭受重大创伤或接受体外循环后的患者会表现出全身炎症反应。这种炎症反应涉及一系列复杂的炎症多肽分子，即细胞因子。人们普遍认为，这些细胞因子释放的局部控制丧失会导致全身炎症以及包括全身炎症反应综合征、多器官功能障碍综合征、休克和死亡在内的潜在有害后果。
方法
在Medline数据库中检索有关全身炎症反应综合征发生机制及调节炎症反应潜在靶点的文献。我们重点关注细胞因子吸附这一有前景的清除技术的新型疗法。
结果
来自人体研究和实验动物模型的越来越多的数据表明，在包括内毒素释放、补体激活、缺血再灌注损伤等多种起始刺激后，促炎和抗炎细胞因子都会释放。
讨论
促炎和抗炎细胞因子以复杂且不可预测的方式相互作用，影响免疫系统并最终导致多个终末器官效应。细胞因子吸附疗法为改善全身炎症反应综合征后的预后提供了一种潜在解决方案。
Zotero 插件