血浆白细胞介素 33 水平在股骨头坏死患者中的变化：股骨头坏死的预警因子？
Plasma interleukin 33 level in patients with osteonecrosis of femoral head: an alarmin for osteonecrosis of the femoral head?
机构信息
From the Department of Orthopedics, 2nd Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.
出版信息
J Investig Med. 2014 Mar;62(3):635-7. doi: 10.2310/JIM.0000000000000050.
OBJECTIVES
This study examines plasma interleukin 33 (IL-33) levels in patients with osteonecrosis of the femoral head (ONFH) and explores the possible use of IL-33 as a marker for early diagnosis and progression of ONFH.
METHODS
One hundred twenty-five ONFH patients and 126 control subjects were recruited for this study. The plasma IL-33 levels were measured using a commercially available enzyme-linked immunosorbent assay kit. Effects of disease stage and risk factors on IL-33 level were also assessed.
RESULTS
Plasma IL-33 levels were significantly higher in the 125 ONFH patients (174.33 [SD, 65.73] pg/mL) than in the 126 control subjects (90.50 [SD, 25.17] pg/mL, P < 0.001). Plasma IL-33 levels were significantly higher in patients with stage III/IV ONFH (184.17 [SD, 43.75] pg/mL) than in patients with stage I/II ONFH (158.24 [SD, 50.11] pg/mL, P < 0.001). There was no significant difference in IL-33 levels between alcohol-induced, idiopathic, and steroid-induced cases.
CONCLUSIONS
Plasma IL-33 may be an alarmin for ONFH, and its levels may be related to disease progression.
目的
本研究检测了骨坏死患者的血浆白细胞介素 33（IL-33）水平，并探讨了 IL-33 作为骨坏死早期诊断和进展的标志物的可能性。
方法
本研究纳入了 125 名骨坏死患者和 126 名对照者。使用商业可得的酶联免疫吸附测定试剂盒测量血浆 IL-33 水平。还评估了疾病分期和危险因素对 IL-33 水平的影响。
结果
125 名骨坏死患者的血浆 IL-33 水平明显高于 126 名对照者（174.33 [标准差，65.73] pg/mL 比 90.50 [标准差，25.17] pg/mL，P<0.001）。III/IV 期骨坏死患者的血浆 IL-33 水平明显高于 I/II 期骨坏死患者（184.17 [标准差，43.75] pg/mL 比 158.24 [标准差，50.11] pg/mL，P<0.001）。酒精性、特发性和类固醇诱导的病例之间的 IL-33 水平无显著差异。
结论
血浆 IL-33 可能是骨坏死的警报素，其水平可能与疾病进展有关。
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