Laxenaire M C, Khamel L, Heravi Z, Manel J, Bois J P
Ann Fr Anesth Reanim. 1987;6(4):230-2. doi: 10.1016/s0750-7658(87)80026-6.
The variations in blood pressure, heart rate and plasma histamine levels were monitored for 10 min in 40 patients at risk of releasing histamine after they had been given 2.5 mg X kg-1 propofol in oil emulsion (n = 20) or 7 mg X kg-1 thiopentone (n = 20). The measurements were carried out before anaesthesia, and 1, 2, 3, 5, 7 and 10 min after injecting the drug. All the patients were premedicated with a specific anti-H1 antagonist only (terfenadine). Histamine was measured by radio-immunology (Immunotech). Two patients from the propofol group and three from the thiopentone group showed minor signs, that may have been linked to a release of histamine. Blood pressure fell in both groups by about 20% (p less than 0.001) within the first minute, becoming stable afterwards. The heart rate did not change significantly. Plasma histamine levels did not change in either group, nor in those patients who had presented a local erythema. Propofol did not seem to induce non-specific histamine release when injected over a period of 60 s in patients at risk of doing so.
对40例有组胺释放风险的患者进行监测，在给予2.5mg/kg丙泊酚乳剂（n = 20）或7mg/kg硫喷妥钠（n = 20）后，监测其血压、心率和血浆组胺水平变化10分钟。测量在麻醉前以及注射药物后1、2、3、5、7和10分钟进行。所有患者仅预先使用一种特异性抗H1拮抗剂（特非那定）。组胺通过放射免疫法（Immunotech）测定。丙泊酚组有2例患者，硫喷妥钠组有3例患者出现可能与组胺释放有关的轻微体征。两组患者血压在第一分钟内均下降约20%（p < 0.001），随后趋于稳定。心率无显著变化。两组患者的血浆组胺水平均未改变，出现局部红斑的患者也是如此。在有组胺释放风险的患者中，丙泊酚在60秒内注射时似乎不会诱导非特异性组胺释放。
