人群血清抵抗素与脂肪摄入量、血脂浓度和肥胖的关系。

Relationships between serum resistin and fat intake, serum lipid concentrations and adiposity in the general population.

机构信息

Research Unit, Nuestra Señora de la Candelaria University Hospital.

出版信息

J Atheroscler Thromb. 2014;21(5):454-62. doi: 10.5551/jat.22103. Epub 2014 Jan 15.

DOI:10.5551/jat.22103

PMID:24430788

Abstract

AIMS

The serum resistin level is associated with the incidence of ischemic heart disease in the general population. We analyzed the associations between serum resistin and fat intake, serum lipid concentrations and adiposity in the general population.

METHODS

A cross-sectional study of 6,637 randomly recruited adults was conducted. The resistin levels were measured in thawed aliquots of serum using an enzyme immunoanalysis technique.

RESULTS

The resistin level exhibited a positive nonparametric correlation with saturated fat intake(p < 0.001) and an inverse correlation with adherence to the Mediterranean diet(p < 0.001), monounsaturated fat intake(p < 0.05), total serum cholesterol(p < 0.001), non-HDL cholesterol(p < 0.001), LDL cholesterol(p < 0.001), body mass index(p < 0.001), waist circumference(p < 0.001) and the waist/height ratio(p < 0.001). An elevated resistin concentration(fifth quintile) was associated with adherence to the Mediterranean diet(OR=0.82 CI95%=0.71-0.93), saturated fat intake(OR=1.34 CI95%=1.16-1.56), monounsaturated fat intake(OR=0.88 CI95%=0.78-0.99), a total cholesterol level of ≥200 mg/dL(OR=0.81 CI95%=0.72-0.91), a low HDL cholesterol level(OR=0.84 CI95%= 0.76-0.93), a high non-HDL cholesterol level(OR=0.84 CI95%=0.72-0.99), a high LDL cholesterol level(OR=0.82 CI95%=0.70-0.97) and a waist/height ratio of ≥0.55(OR=0.76 CI95%=0.67-0.85). The multivariate models corroborated the positive associations between the resistin level and saturated fat intake(p < 0.001) and serum triglycerides(p=0.004) and the inverse associations between the resistin level and adherence to the Mediterranean diet(p=0.002), total serum cholesterol(p < 0.001) and cholesterol fractions and the waist/height ratio(p=0.02).

CONCLUSIONS

In the general population, the serum resistin level is associated with fat intake: positively with saturated fat intake and inversely with monounsaturated fat intake. As a consequence, the resistin level is also inversely associated with adherence to the Mediterranean diet. In addition, the resistin level is inversely associated with the serum cholesterol level and adiposity.

摘要

目的

血清抵抗素水平与普通人群中缺血性心脏病的发生率有关。我们分析了血清抵抗素与脂肪摄入、血清脂质浓度和肥胖在普通人群中的关系。

方法

对 6637 名随机招募的成年人进行了一项横断面研究。使用酶免疫分析技术检测解冻血清中的抵抗素水平。

结果

抵抗素水平与饱和脂肪摄入呈正非参数相关（p<0.001），与地中海饮食依从性呈负相关（p<0.001），与单不饱和脂肪摄入呈负相关（p<0.05），与总血清胆固醇呈负相关（p<0.001），与非高密度脂蛋白胆固醇呈负相关（p<0.001），与低密度脂蛋白胆固醇呈负相关（p<0.001），与体重指数呈负相关（p<0.001），与腰围呈负相关（p<0.001），与腰高比呈负相关（p<0.001）。高浓度的抵抗素（第五五分位）与地中海饮食依从性相关（OR=0.82 CI95%=0.71-0.93），与饱和脂肪摄入相关（OR=1.34 CI95%=1.16-1.56），与单不饱和脂肪摄入相关（OR=0.88 CI95%=0.78-0.99），与总胆固醇水平≥200mg/dL 相关（OR=0.81 CI95%=0.72-0.91），与低高密度脂蛋白胆固醇水平相关（OR=0.84 CI95%=0.76-0.93），与高非高密度脂蛋白胆固醇水平相关（OR=0.84 CI95%=0.72-0.99），与高 LDL 胆固醇水平相关（OR=0.82 CI95%=0.70-0.97），与腰高比≥0.55 相关（OR=0.76 CI95%=0.67-0.85）。多元模型证实了抵抗素水平与饱和脂肪摄入（p<0.001）和血清甘油三酯（p=0.004）之间的正相关，以及与地中海饮食依从性（p=0.002）、总血清胆固醇（p<0.001）和胆固醇分数以及腰高比（p=0.02）之间的负相关。