Elliott Alison M, Burton Christopher D, Hannaford Philip C
Centre of Academic Primary Care, Division of Applied Health Sciences, University of Aberdeen, Foresterhill, Aberdeen, UK.
BMJ Open. 2014 Jan 14;4(1):e003917. doi: 10.1136/bmjopen-2013-003917.
To examine 10-year mortality and hospital use among individuals categorised as resilient and vulnerable to the impact of chronic pain.
A cohort record linkage study.
Grampian, Scotland.
5858 individuals from the Grampian Pain Cohort, established in 1996, were linked, by probability matching, with national routinely collected datasets.
HRs for subsequent 10-year mortality and ORs/incidence rate ratios for subsequent 10-year hospital use, each with adjustment for potential confounding variables.
36.5% of those with high pain intensity reported a low pain-related disability (categorised resilient) and 7.1% of those reporting low pain intensity reported a high pain-related disability (categorised vulnerable). Sex, age, housing, employment and long-term limiting illness were independently associated with being vulnerable or resilient. After adjustment for these variables, individuals in the resilient group were 25% less likely to die within 10 years of the survey compared with non-resilient individuals: HR 0.75, 95% CI 0.62 to 0.91 and vulnerable individuals were 45% more likely to die than non-vulnerable individuals: HR 1.45, 95% CI 1.01 to 2.11. Resilient individuals were less likely to have had an outpatient or day-case visit for anaesthetics: OR 0.46, 95% CI 0.27 to 0.79, but no other clinical specialities. Vulnerable individuals were significantly less likely to have had any outpatient or day-case visit (OR 0.43, 0.25 to 0.75); but more likely to have had a psychiatric visit (OR 1.96, 1.06 to 3.61). No significant differences in likelihood of any inpatient visits were found.
Resilient individuals have a better 10-year survival than non-resilient individuals indicating that resilience is a phenomenon worth researching. Further research is needed to explore who is likely to become resilient, why and how, as well as to tease out the internal and external factors that influence resilience.
研究被归类为对慢性疼痛影响具有恢复力和易受影响的个体的10年死亡率和医院就诊情况。
队列记录链接研究。
苏格兰格兰扁地区。
1996年建立的格兰扁疼痛队列中的5858名个体通过概率匹配与国家常规收集的数据集相链接。
后续10年死亡率的风险比(HRs)以及后续10年医院就诊的比值比(ORs)/发病率比,均对潜在混杂变量进行了调整。
疼痛强度高的个体中,36.5%报告疼痛相关残疾程度低(归类为恢复力强);疼痛强度低的个体中,7.1%报告疼痛相关残疾程度高(归类为易受影响)。性别、年龄、住房、就业和长期限制性疾病与易受影响或恢复力强独立相关。在对这些变量进行调整后,与无恢复力的个体相比,恢复力强的组中的个体在调查后10年内死亡的可能性低25%:HR为0.75,95%置信区间为0.62至0.91;易受影响的个体比不易受影响的个体死亡可能性高45%:HR为1.45,95%置信区间为1.01至2.11。恢复力强的个体接受麻醉门诊或日间手术就诊的可能性较小:OR为0.46,95%置信区间为0.27至0.79,但其他临床专科无此情况。易受影响的个体进行任何门诊或日间手术就诊的可能性显著较低(OR为0.43,0.25至0.75);但进行精神科就诊的可能性较高(OR为1.96,1.06至3.61)。在任何住院就诊可能性方面未发现显著差异。
恢复力强的个体10年生存率高于无恢复力的个体,这表明恢复力是一个值得研究的现象。需要进一步研究以探索谁可能变得具有恢复力、原因和方式,以及梳理出影响恢复力的内部和外部因素。