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合成代谢剂克仑特罗对超负荷大鼠骨骼肌的影响。

The effect of the anabolic agent, clenbuterol, on overloaded rat skeletal muscle.

作者信息

Maltin C A, Delday M I, Hay S M, Smith F G, Lobley G E, Reeds P J

机构信息

Rowett Research Institute, Bucksburn, Aberdeen.

出版信息

Biosci Rep. 1987 Feb;7(2):143-9. doi: 10.1007/BF01121878.

DOI:10.1007/BF01121878
PMID:2443196
Abstract

The dietary administration of clenbuterol to young male rats has been shown to produce a muscle specific hypertrophic growth response. This paper demonstrates that the combined effect of drug treatment and hypertrophic stimulus induced by tenotomy produced an additive effect on muscle growth. This effect was demonstrated in terms of both muscle composition (protein and RNA) and fibre size.

摘要

已表明,对幼年雄性大鼠进行克伦特罗饮食给药可产生肌肉特异性肥大生长反应。本文证明,药物治疗与肌腱切断术诱导的肥大刺激的联合作用对肌肉生长产生了累加效应。这种效应在肌肉组成(蛋白质和RNA)和纤维大小方面均得到了证实。

相似文献

1
The effect of the anabolic agent, clenbuterol, on overloaded rat skeletal muscle.合成代谢剂克仑特罗对超负荷大鼠骨骼肌的影响。
Biosci Rep. 1987 Feb;7(2):143-9. doi: 10.1007/BF01121878.
2
The effect of a growth promoting drug, clenbuterol, on fibre frequency and area in hind limb muscles from young male rats.一种促生长药物克伦特罗对年轻雄性大鼠后肢肌肉纤维频率和面积的影响。
Biosci Rep. 1986 Mar;6(3):293-9. doi: 10.1007/BF01115158.
3
Propranolol apparently separates the physical and compositional characteristics of muscle growth induced by clenbuterol.普萘洛尔显然区分了克伦特罗诱导的肌肉生长的生理和成分特征。
Biosci Rep. 1987 Jan;7(1):51-7. doi: 10.1007/BF01122727.
4
Clenbuterol, a beta agonist, induces growth in innervated and denervated rat soleus muscle via apparently different mechanisms.克仑特罗,一种β激动剂,通过明显不同的机制诱导去神经支配和未去神经支配的大鼠比目鱼肌生长。
Biosci Rep. 1987 Jun;7(6):525-32. doi: 10.1007/BF01116510.
5
Clenbuterol prevents or inhibits loss of specific mRNAs in atrophying rat skeletal muscle.
Am J Physiol. 1988 May;254(5 Pt 1):C657-60. doi: 10.1152/ajpcell.1988.254.5.C657.
6
Evidence that the hypertrophic action of clenbuterol on denervated rat muscle is not propranolol-sensitive.克仑特罗对去神经大鼠肌肉的肥大作用不受普萘洛尔影响的证据。
Br J Pharmacol. 1989 Apr;96(4):817-22. doi: 10.1111/j.1476-5381.1989.tb11889.x.
7
The action of the beta-agonist clenbuterol on protein metabolism in innervated and denervated phasic muscles.β-激动剂克仑特罗对有神经支配和去神经支配的相性肌肉蛋白质代谢的作用。
Biochem J. 1989 Aug 1;261(3):965-71. doi: 10.1042/bj2610965.
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Protein turnover and growth of L8 muscle cultures in serum from rats fed clenbuterol.喂食克伦特罗的大鼠血清中L8肌肉培养物的蛋白质周转与生长
Growth Dev Aging. 1988 Winter;52(4):185-91.
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Clenbuterol increases the expression of myogenin but not myoD in immobilized rat muscles.
Am J Physiol. 1997 May;272(5 Pt 1):E941-4. doi: 10.1152/ajpendo.1997.272.5.E941.
10
Effects of clenbuterol and propranolol on muscle mass. Evidence that clenbuterol stimulates muscle beta-adrenoceptors to induce hypertrophy.克伦特罗和普萘洛尔对肌肉质量的影响。有证据表明克伦特罗刺激肌肉β-肾上腺素能受体以诱导肥大。
Biochem J. 1989 Dec 1;264(2):573-9. doi: 10.1042/bj2640573.

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Mechanisms of mechanical overload-induced skeletal muscle hypertrophy: current understanding and future directions.机械过载诱导骨骼肌肥大的机制:当前认识和未来方向。
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Egg White Protein Feeding Facilitates Skeletal Muscle Gain in Young Rats with/without Clenbuterol Treatment.
蛋清蛋白喂养促进未用/用克仑特罗处理的幼鼠的骨骼肌生长。
Nutrients. 2021 Jun 15;13(6):2042. doi: 10.3390/nu13062042.
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Effects of β2-adrenergic stimulation on exercise capacity in normal subjects.β2 肾上腺素能刺激对正常受试者运动能力的影响。
Eur J Appl Physiol. 2011 Sep;111(9):2239-47. doi: 10.1007/s00421-011-1856-9. Epub 2011 Feb 16.
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Molecular impact of clenbuterol and isometric strength training on rat EDL muscles.克伦特罗和等长力量训练对大鼠趾长伸肌的分子影响。
Pflugers Arch. 2007 Jan;453(4):497-507. doi: 10.1007/s00424-006-0122-1. Epub 2006 Nov 9.
6
Evidence that the hypertrophic action of clenbuterol on denervated rat muscle is not propranolol-sensitive.克仑特罗对去神经大鼠肌肉的肥大作用不受普萘洛尔影响的证据。
Br J Pharmacol. 1989 Apr;96(4):817-22. doi: 10.1111/j.1476-5381.1989.tb11889.x.
7
Regulation of protein turnover in skeletal and cardiac muscle.骨骼肌和心肌中蛋白质周转的调节。
Biochem J. 1991 Jan 1;273(Pt 1)(Pt 1):21-37. doi: 10.1042/bj2730021.
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The effects of clenbuterol on satellite cell activation and the regeneration of skeletal muscle: an autoradiographic and morphometric study of whole muscle transplants in mice.克伦特罗对卫星细胞激活及骨骼肌再生的影响:小鼠全肌移植的放射自显影和形态计量学研究
J Anat. 1992 Feb;180 ( Pt 1)(Pt 1):57-65.