克仑特罗对去神经大鼠肌肉的肥大作用不受普萘洛尔影响的证据。
Evidence that the hypertrophic action of clenbuterol on denervated rat muscle is not propranolol-sensitive.
作者信息
Maltin C A, Hay S M, Delday M I, Reeds P J, Palmer R M
机构信息
Rowett Research Institute, Bucksburn, Aberdeen.
出版信息
Br J Pharmacol. 1989 Apr;96(4):817-22. doi: 10.1111/j.1476-5381.1989.tb11889.x.
Abstract
- The effect of propranolol on the clenbuterol-induced protein anabolism in innervated and denervated soleus and plantaris muscles of the rat was studied. 2. The response to the beta-agonist, clenbuterol, in both innervated and denervated muscles, was not significantly inhibited by the beta-antagonist, propranolol. 3. The results provide further evidence to suggest that the action of clenbuterol on skeletal muscle protein accretion may not be directly mediated by beta-adrenoceptors.
摘要
- 研究了普萘洛尔对大鼠有神经支配和去神经支配的比目鱼肌和跖肌中克伦特罗诱导的蛋白质合成代谢的影响。2. 在有神经支配和去神经支配的肌肉中，β受体拮抗剂普萘洛尔对β激动剂克伦特罗的反应均未受到显著抑制。3. 这些结果提供了进一步的证据，表明克伦特罗对骨骼肌蛋白质积累的作用可能不是由β肾上腺素能受体直接介导的。
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