β-激动剂克仑特罗对有神经支配和去神经支配的相性肌肉蛋白质代谢的作用。
The action of the beta-agonist clenbuterol on protein metabolism in innervated and denervated phasic muscles.
作者信息
Maltin C A, Hay S M, Delday M I, Lobley G E, Reeds P J
机构信息
Rowett Research Institute, Bucksburn, Aberdeen, U.K.
出版信息
Biochem J. 1989 Aug 1;261(3):965-71. doi: 10.1042/bj2610965.
Abstract
- Clenbuterol treatment in innervated and denervated phasic extensor digitorum longus, plantaris and gastrocnemius muscles from rats caused a significant increase in RNA and protein contents in all muscles except denervated extensor digitorum longus. 2. All muscles showed an increase in the fractional rate of protein synthesis (Ks) with clenbuterol, but the temporal response varied. 3. The data suggest that the effect of clenbuterol on protein metabolism in innervated muscles is muscle-type specific, and demonstrate the homology of response for denervated muscles.
摘要
- 对大鼠受神经支配和去神经支配的腓肠肌、比目鱼肌和趾长伸肌进行克伦特罗处理后，除去神经支配的趾长伸肌外，所有肌肉的RNA和蛋白质含量均显著增加。2. 所有肌肉在使用克伦特罗后蛋白质合成分数率（Ks）均增加，但时间反应有所不同。3. 数据表明，克伦特罗对受神经支配肌肉蛋白质代谢的影响具有肌肉类型特异性，并证明了去神经支配肌肉反应的同源性。
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