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Expression and modification of keratins during terminal differentiation of mammalian epidermis.

作者信息

Bowden P E, Stark H J, Breitkreutz D, Fusenig N E

机构信息

Institute of Biochemistry, German Cancer Research Center (DKFZ), Heidelberg.

出版信息

Curr Top Dev Biol. 1987;22:35-68. doi: 10.1016/s0070-2153(08)60098-8.

DOI:10.1016/s0070-2153(08)60098-8
PMID:2443315
Abstract
摘要

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Expression and modification of keratins during terminal differentiation of mammalian epidermis.哺乳动物表皮终末分化过程中角蛋白的表达与修饰
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Changes in keratin gene expression during terminal differentiation of the keratinocyte.角质形成细胞终末分化过程中角蛋白基因表达的变化。
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Use of monospecific antisera and cRNA probes to localize the major changes in keratin expression during normal and abnormal epidermal differentiation.使用单特异性抗血清和cRNA探针来定位正常和异常表皮分化过程中角蛋白表达的主要变化。
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Expression of unusually large keratins during terminal differentiation: balance of type I and type II keratins is not disrupted.终末分化过程中异常大角蛋白的表达：I型和II型角蛋白的平衡未被破坏。
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Monospecific monoclonal antibodies to keratin 1 carboxy terminal (synthetic peptide) and to keratin 10 as markers of epidermal differentiation.针对角蛋白1羧基末端（合成肽）和角蛋白10的单特异性单克隆抗体，作为表皮分化的标志物。
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The use of retinoic acid to probe the relation between hyperproliferation-associated keratins and cell proliferation in normal and malignant epidermal cells.使用视黄酸探究正常和恶性表皮细胞中与过度增殖相关的角蛋白和细胞增殖之间的关系。
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The sheep KAP8-2 gene, a new KAP8 family member that is absent in humans.绵羊KAP8-2基因，一种人类所没有的KAP8家族新成员。
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Characterization of the pattern of cytokeratin proteins in the epidermal cells of loach,Misgurnus anguillicaudatus (Cyprinformes).泥鳅（鲤形目）表皮细胞角蛋白蛋白的特征分析。
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Keratin 16-null mice develop palmoplantar keratoderma, a hallmark feature of pachyonychia congenita and related disorders.
角蛋白 16 缺失小鼠会出现掌跖角化过度症，这是先天性厚甲症和相关疾病的一个显著特征。
J Invest Dermatol. 2012 May;132(5):1384-91. doi: 10.1038/jid.2012.6. Epub 2012 Feb 16.
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Mutual induction of growth factor gene expression by epidermal-dermal cell interaction.表皮-真皮细胞相互作用对生长因子基因表达的相互诱导作用。
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Keratinization of the outer surface of the avian scutate scale: interrelationship of alpha and beta keratin filaments in a cornifying tissue.
Cell Tissue Res. 1989 Jul;257(1):85-92. doi: 10.1007/BF00221637.
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Two type II keratin genes are localized on human chromosome 12.两个II型角蛋白基因定位于人类12号染色体上。
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