Gindiciosi B, Palus V, Eminaga S, Villiers E, Bruto Cherubini G
Dick White Referrals, Cambridgeshire, CB8 0UH.
J Small Anim Pract. 2014 Feb;55(2):108-11. doi: 10.1111/jsap.12173. Epub 2014 Jan 16.
To determine serum bromide concentrations following an oral loading dose in dogs.
Retrospective review of clinical records of dogs suffering from seizures that were treated with bromide. A loading dose of 600 mg/kg potassium bromide was administered orally in 17 to 48 hours together with a maintenance dose of 30 mg/kg/day. Blood samples were collected within 24 hours after completing the protocol and serum bromide concentrations were determined by ultra-violet gold chloride colorimetric assay.
Thirty-eight dogs were included in the study. The median age was 3 (range, 0 · 2 to 10) years and bodyweight 21 · 8 (3 · 45 to 46 · 2) kg. The median serum bromide concentration was 1 · 26 (0 · 74 to 3 · 6) mg/mL. Thirty-two dogs (84 · 2%) had serum bromide concentrations within the therapeutic interval (1 to 3 mg/mL). The serum concentration in five dogs (13 · 2%) was just under the minimal therapeutic value and in one dog (2 · 6%) it exceeded the maximal therapeutic value (3 · 6 mg/mL).
Following this oral loading dose protocol, serum bromide concentrations reach the therapeutic range in the majority of dogs. This indicates that the suggested protocol is effective in achieving therapeutic concentrations rapidly in epileptic dogs.
测定犬口服负荷剂量后血清溴化物浓度。
回顾性分析接受溴化物治疗的癫痫犬的临床记录。在17至48小时内口服600mg/kg溴化钾负荷剂量，同时给予30mg/kg/天的维持剂量。在完成方案后24小时内采集血样，采用紫外氯化金比色法测定血清溴化物浓度。
38只犬纳入研究。中位年龄为3（范围0.2至10）岁，体重21.8（3.45至46.2）kg。血清溴化物中位浓度为1.26（0.74至3.6）mg/mL。32只犬（84.2%）血清溴化物浓度在治疗区间（1至3mg/mL）内。5只犬（13.2%）的血清浓度略低于最小治疗值，1只犬（2.6%）超过最大治疗值（3.6mg/mL）。
按照该口服负荷剂量方案，大多数犬的血清溴化物浓度达到治疗范围。这表明所建议的方案能有效快速地使癫痫犬达到治疗浓度。
