Shaw N, Trepanier L A, Center S A, Garland S
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.
J Am Vet Med Assoc. 1996 Jan 15;208(2):234-6.
Bromide treatment was successful in controlling seizures in an 11-year-old Dachshund with epilepsy and presumptive phenobarbital-associated hepatopathy. Because bromide does not induce liver enzyme activity and does not seem to be hepatotoxic, it can be used to control seizures in dogs with concurrent epilepsy and hepatic disease. In this dog, institution of a special calculolytic diet with high chloride content was associated with a decrease in serum bromide concentrations and the recurrence of seizures. High chloride intake increases the elimination of bromide in dogs, leading to higher dosage requirements for bromide in dogs fed high-chloride diets.
溴化物治疗成功地控制了一只患有癫痫和疑似苯巴比妥相关肝病的11岁腊肠犬的癫痫发作。由于溴化物不会诱导肝酶活性，似乎也没有肝毒性，因此可用于控制同时患有癫痫和肝病的犬的癫痫发作。在这只犬中，采用高氯含量的特殊抗结石饮食与血清溴化物浓度降低和癫痫复发有关。高氯摄入量会增加犬体内溴化物的排泄，导致喂食高氯饮食的犬对溴化物的剂量需求更高。
