肿瘤坏死因子受体相关因子 3（TRAF3）在淋巴细胞功能中的作用。
Roles for TNF-receptor associated factor 3 (TRAF3) in lymphocyte functions.
机构信息
Department of Microbiology, The University of Iowa, USA.
The Graduate Program in Immunology, The University of Iowa, USA.
出版信息
Cytokine Growth Factor Rev. 2014 Apr;25(2):147-56. doi: 10.1016/j.cytogfr.2013.12.002. Epub 2013 Dec 25.
Abstract
TRAF3 is an adapter protein that serves and regulates the functions of several types of receptors, located both inside the cell and at the plasma membrane. These include members of the TNF receptor superfamily (TNFR-SF), toll-like receptors (TLR), and cytokine receptors. It has become increasingly evident that the roles and functions of TRAF3 are highly context-dependent. TRAF3 can serve distinct roles for different receptors in the same cell, and also has highly cell-type-dependent functions. This review focuses upon the current state of knowledge regarding how TRAF3 regulates the biology and effector functions of B and T lymphocytes, two major cell types of the adaptive immune response in which TRAF3 has markedly distinct roles.
摘要
TRAF3 是一种衔接蛋白，既能在细胞内，也能在质膜上，为多种类型的受体提供服务并调节其功能。这些受体包括肿瘤坏死因子受体超家族（TNFR-SF）成员、 Toll 样受体（TLR）和细胞因子受体。越来越明显的是，TRAF3 的作用和功能高度依赖于背景。TRAF3 可以为同一细胞中不同的受体提供不同的作用，并且具有高度依赖细胞类型的功能。本综述重点介绍了目前关于 TRAF3 如何调节 B 和 T 淋巴细胞生物学和效应功能的知识状态，TRAF3 在这两种适应性免疫反应的主要细胞类型中具有显著不同的作用。
相似文献
1
Roles for TNF-receptor associated factor 3 (TRAF3) in lymphocyte functions.肿瘤坏死因子受体相关因子 3（TRAF3）在淋巴细胞功能中的作用。
Cytokine Growth Factor Rev. 2014 Apr;25(2):147-56. doi: 10.1016/j.cytogfr.2013.12.002. Epub 2013 Dec 25.
2
Roles of tumor necrosis factor receptor associated factor 3 (TRAF3) and TRAF5 in immune cell functions.肿瘤坏死因子受体相关因子 3（TRAF3）和 TRAF5 在免疫细胞功能中的作用。
Immunol Rev. 2011 Nov;244(1):55-74. doi: 10.1111/j.1600-065X.2011.01055.x.
3
TRAF3 as a powerful and multitalented regulator of lymphocyte functions.TRAF3作为淋巴细胞功能的强大且多才多艺的调节因子。
J Leukoc Biol. 2016 Nov;100(5):919-926. doi: 10.1189/jlb.2MR0216-063R. Epub 2016 May 6.
4
TRAF3 as a Multifaceted Regulator of B Lymphocyte Survival and Activation.TRAF3 作为 B 淋巴细胞存活和激活的多功能调节因子。
Front Immunol. 2018 Sep 24;9:2161. doi: 10.3389/fimmu.2018.02161. eCollection 2018.
5
Roles of TRAF3 in T cells: many surprises.肿瘤坏死因子受体相关因子3（TRAF3）在T细胞中的作用：诸多意外发现。
Cell Cycle. 2015;14(8):1156-63. doi: 10.1080/15384101.2015.1021524.
6
TRAF3 regulation of proximal TLR signaling in B cells.TRAF3 调节 B 细胞中 TLR 信号的近端反应。
J Leukoc Biol. 2024 Jul 25;116(2):210-223. doi: 10.1093/jleuko/qiae038.
7
Multiple roles of TRAF3 signaling in lymphocyte function.TRAF3信号在淋巴细胞功能中的多种作用。
Immunol Res. 2007;39(1-3):22-32. doi: 10.1007/s12026-007-0068-1.
8
Expanding TRAF function: TRAF3 as a tri-faced immune regulator.拓展 TRAF 功能：TRAF3 作为一个三面向的免疫调控因子。
Nat Rev Immunol. 2011 Jun 10;11(7):457-68. doi: 10.1038/nri2998.
9
Multiple mechanisms for TRAF3-mediated regulation of the T cell costimulatory receptor GITR.TRAF3 介导的调节 T 细胞共刺激受体 GITR 的多种机制。
J Biol Chem. 2021 Sep;297(3):101097. doi: 10.1016/j.jbc.2021.101097. Epub 2021 Aug 18.
10
TRAF3, ubiquitination, and B-lymphocyte regulation.肿瘤坏死因子受体相关因子3、泛素化与B淋巴细胞调节
Immunol Rev. 2015 Jul;266(1):46-55. doi: 10.1111/imr.12299.
引用本文的文献
1
Otubain 2 stabilizes TNF‑receptor associated factor 3 to accelerate bone fracture healing.卵巢肿瘤蛋白酶体激活因子2稳定肿瘤坏死因子受体相关因子3以加速骨折愈合。
Mol Med Rep. 2025 Aug;32(2). doi: 10.3892/mmr.2025.13588. Epub 2025 Jun 6.
2
Targeting transcription-replication conflicts using G-quadruplexes stabilizers in multiple myeloma.在多发性骨髓瘤中使用G-四链体稳定剂靶向转录-复制冲突。
Blood Neoplasia. 2025 Jan 20;2(2):100072. doi: 10.1016/j.bneo.2025.100072. eCollection 2025 May.
3
The Roles of TRAF3 in Immune Responses.TRAF3 在免疫应答中的作用。
Dis Markers. 2023 Feb 16;2023:7787803. doi: 10.1155/2023/7787803. eCollection 2023.
4
Excess BAFF Alters NR4As Expression Levels and Breg Function of Human Precursor-like Marginal Zone B-Cells in the Context of HIV-1 Infection.过量 BAFF 改变 HIV-1 感染中人前体样边缘区 B 细胞中 NR4As 的表达水平和 Breg 功能。
Int J Mol Sci. 2022 Dec 1;23(23):15142. doi: 10.3390/ijms232315142.
5
Extracellular fibrinogen-binding protein released by intracellular Staphylococcus aureus suppresses host immunity by targeting TRAF3.胞内金黄色葡萄球菌释放的细胞外纤维蛋白原结合蛋白通过靶向 TRAF3 抑制宿主免疫。
Nat Commun. 2022 Sep 19;13(1):5493. doi: 10.1038/s41467-022-33205-z.
6
HSF1 Protects Sepsis-Induced Acute Lung Injury by Inhibiting NLRP3 Inflammasome Activation.热休克因子1通过抑制NLRP3炎性小体激活来保护脓毒症诱导的急性肺损伤。
Front Immunol. 2022 Jun 1;13:781003. doi: 10.3389/fimmu.2022.781003. eCollection 2022.
7
miR-361-5p regulates ovarian cancer cell proliferation and apoptosis by targeting TRAF3.微小RNA-361-5p通过靶向肿瘤坏死因子受体相关因子3调控卵巢癌细胞的增殖和凋亡。
Exp Ther Med. 2021 Mar;21(3):199. doi: 10.3892/etm.2021.9632. Epub 2021 Jan 11.
8
TRAF3 mediates neuronal apoptosis in early brain injury following subarachnoid hemorrhage via targeting TAK1-dependent MAPKs and NF-κB pathways.TRAF3 通过靶向 TAK1 依赖性 MAPKs 和 NF-κB 通路介导蛛网膜下腔出血后早期脑损伤中的神经元凋亡。
Cell Death Dis. 2021 Jan 7;12(1):10. doi: 10.1038/s41419-020-03278-z.
9
MicroRNA-29b-3p reduces intestinal ischaemia/reperfusion injury via targeting of TNF receptor-associated factor 3.microRNA-29b-3p 通过靶向 TNF 受体相关因子 3 减少肠道缺血/再灌注损伤。
Br J Pharmacol. 2019 Sep;176(17):3264-3278. doi: 10.1111/bph.14759. Epub 2019 Jul 17.
10
Molecular signaling in bone cells: Regulation of cell differentiation and survival.骨细胞中的分子信号转导：细胞分化和存活的调节。
Adv Protein Chem Struct Biol. 2019;116:237-281. doi: 10.1016/bs.apcsb.2019.01.002. Epub 2019 Feb 4.
本文引用的文献
1
A Complex Relationship between TRAF3 and Non-Canonical NF-κB2 Activation in B Lymphocytes.TRAF3 与 B 淋巴细胞中非经典 NF-κB2 激活之间的复杂关系。
Front Immunol. 2013 Dec 20;4:477. doi: 10.3389/fimmu.2013.00477. eCollection 2013.
2
TRAF5 negatively regulates TLR signaling in B lymphocytes.TRAF5 负调控 B 淋巴细胞中的 TLR 信号转导。
J Immunol. 2014 Jan 1;192(1):145-50. doi: 10.4049/jimmunol.1301901. Epub 2013 Nov 20.
3
Cell-intrinsic role for NF-kappa B-inducing kinase in peripheral maintenance but not thymic development of Foxp3+ regulatory T cells in mice.NF-κB 诱导激酶在小鼠外周维持而非胸腺发育中对 Foxp3+调节性 T 细胞的细胞内固有作用。
PLoS One. 2013 Sep 20;8(9):e76216. doi: 10.1371/journal.pone.0076216. eCollection 2013.
4
The contextual role of TNFR family members in CD8(+) T-cell control of viral infections.TNFR 家族成员在 CD8(+) T 细胞控制病毒感染中的语境作用。
Immunol Rev. 2013 Sep;255(1):125-48. doi: 10.1111/imr.12086.
5
Toll-like receptor regulation of effector T lymphocyte function. Toll 样受体对效应 T 淋巴细胞功能的调节。
Trends Immunol. 2013 Oct;34(10):511-9. doi: 10.1016/j.it.2013.06.003. Epub 2013 Jul 22.
6
4-1BB signaling activates the t cell factor 1 effector/β-catenin pathway with delayed kinetics via ERK signaling and delayed PI3K/AKT activation to promote the proliferation of CD8+ T Cells.4-1BB 信号通过 ERK 信号和延迟的 PI3K/AKT 激活以延迟动力学激活 T 细胞因子 1 效应子/β-连环蛋白途径，从而促进 CD8+T 细胞的增殖。
PLoS One. 2013 Jul 11;8(7):e69677. doi: 10.1371/journal.pone.0069677. Print 2013.
7
Reprogramming of murine macrophages through TLR2 confers viral resistance via TRAF3-mediated, enhanced interferon production.通过 TLR2 对小鼠巨噬细胞进行重编程可通过 TRAF3 介导的增强干扰素产生来赋予抗病毒抗性。
PLoS Pathog. 2013;9(7):e1003479. doi: 10.1371/journal.ppat.1003479. Epub 2013 Jul 11.
8
Regulation of PI-3-Kinase and Akt Signaling in T Lymphocytes and Other Cells by TNFR Family Molecules.肿瘤坏死因子受体家族分子对 T 淋巴细胞和其他细胞中 PI-3-激酶和 Akt 信号的调节。
Front Immunol. 2013 Jun 7;4:139. doi: 10.3389/fimmu.2013.00139. eCollection 2013.
9
TNF receptor associated factor 3 plays a key role in development and function of invariant natural killer T cells.肿瘤坏死因子受体相关因子 3 在不变自然杀伤 T 细胞的发育和功能中发挥关键作用。
J Exp Med. 2013 Jun 3;210(6):1079-86. doi: 10.1084/jem.20122135. Epub 2013 May 6.
10
Noncanonical NF-κB activation by the oncoprotein Tio occurs through a nonconserved TRAF3-binding motif.致癌蛋白 Tio 通过非保守的 TRAF3 结合基序非规范激活 NF-κB。
Sci Signal. 2013 Apr 23;6(272):ra27. doi: 10.1126/scisignal.2003309.
Zotero 插件