Aarhus University Hospital, Aarhus, and North Denmark Regional Hospital, Hjoerring, Denmark.
Aarhus University, Aarhus, Denmark.
Arthritis Care Res (Hoboken). 2019 Jun;71(6):777-786. doi: 10.1002/acr.23694. Epub 2019 Apr 23.
To investigate the relationship between bioimpedance-derived total body fat percentage, waist circumference, and body mass index (BMI) and the subsequent development of rheumatoid arthritis (RA).
A population-based prospective cohort study was conducted using 55,037 patients enrolled in the Danish Diet, Cancer, and Health cohort. Baseline data included anthropometric measures and lifestyle factors. Individuals who developed RA were identified through linkage with the Danish National Patient Registry. The relationships between bioimpedance-derived body fat percentage, waist circumference, and BMI and incident RA were assessed using Cox proportional hazards regression models, stratifying by sex. All analyses were performed for overall RA and the serologic subtypes seropositive and other RA.
A total of 210 men (37.6% with seropositive RA) and 456 women (41.0% with seropositive RA) developed RA during a median follow-up of 20.1 years. In women, the overall RA risk was 10% higher for each 5% increment of total body fat (hazard ratio [HR] 1.10 [95% confidence interval (95% CI) 1.02-1.18]), 5% higher for each 5-cm increment of waist circumference (HR 1.05 [95% CI 1.01-1.10]), and nearly 50% higher in those whose BMI was in the obese range compared to normal range BMI (HR 1.46 [95% CI 1.12-1.90]). These positive associations were also found for patients with other RA. In men, there were no clear associations between body fat percentage, waist circumference, or BMI and RA. No significant associations were found for seropositive RA in women or men, possibly related to low sample size.
In women, higher body fat percentage, higher waist circumference, and obesity were associated with a higher risk of RA.
研究生物阻抗法测量的体脂肪百分比、腰围和体重指数（BMI）与类风湿关节炎（RA）发病的关系。
采用丹麦饮食、癌症和健康队列中的 55037 名患者进行了一项基于人群的前瞻性队列研究。基线数据包括人体测量学指标和生活方式因素。通过与丹麦国家患者登记处的链接，确定发生 RA 的个体。使用 Cox 比例风险回归模型，按性别分层，评估生物阻抗法测量的体脂肪百分比、腰围和 BMI 与新发 RA 之间的关系。所有分析均针对总体 RA 以及血清阳性和其他 RA 的血清亚型进行。
共有 210 名男性（37.6%为血清阳性 RA）和 456 名女性（41.0%为血清阳性 RA）在中位随访 20.1 年后发生 RA。在女性中，全身脂肪每增加 5%，总体 RA 风险增加 10%（危险比[HR]1.10[95%置信区间（95%CI）1.02-1.18]），腰围每增加 5cm，风险增加 5%（HR 1.05[95%CI 1.01-1.10]），BMI 处于肥胖范围的个体与 BMI 处于正常范围的个体相比，风险增加近 50%（HR 1.46[95%CI 1.12-1.90]）。这些正相关关系也在其他 RA 患者中得到了证实。在男性中，体脂肪百分比、腰围或 BMI 与 RA 之间没有明显的相关性。在女性或男性中，血清阳性 RA 与这些因素之间没有显著的相关性，这可能与样本量较小有关。
在女性中，体脂肪百分比较高、腰围较大和肥胖与 RA 风险增加相关。
