Ganguly A K, Sathiamoorthy S S, Bhatnagar O P
Q J Exp Physiol Cogn Med Sci. 1978 Jan;63(1):89-92. doi: 10.1113/expphysiol.1978.sp002419.
Gastric mucosal mast cell population was studied following sub-diaphragmatic vagotomy in albino rats, 6 and 12 h after pylorus ligation. Sub-diaphragmatic vagotomy significantly increased the gastric mucosal mast cell population in both 6 and 12 h groups, the increase being more in the latter. The results suggest that the vagal impulses act on the gastric mucosal mast cells causing their degranulation. Following vagotomy the contents stay bound within the mast cells. Increase in mast cell population with the longer experimental situation was possibly due to the continuation of normal turnover of the mast cells in the gastric mucosa. The present study, however, does not lead to a conclusion that the vagal influence on mast cell population is similar throughout the gastro-intestinal tract.
在幽门结扎6小时和12小时后，对白化大鼠进行膈下迷走神经切断术后，研究了胃黏膜肥大细胞群体。膈下迷走神经切断术显著增加了6小时组和12小时组的胃黏膜肥大细胞群体，后者增加更为明显。结果表明，迷走神经冲动作用于胃黏膜肥大细胞，导致其脱颗粒。迷走神经切断术后，内容物保留在肥大细胞内。随着实验时间延长肥大细胞群体增加，可能是由于胃黏膜中肥大细胞正常更新的持续。然而，本研究并未得出迷走神经对整个胃肠道肥大细胞群体的影响相似的结论。
